Amodil
Generic Name
Modafinil
Manufacturer
Sun Pharmaceutical Industries Ltd.
Country
India
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Description
Overview of the medicine
Modafinil is a wakefulness-promoting agent used for narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea.
Uses & Indications
Dosage
Adults
200 mg orally once daily in the morning.
Elderly
Lower doses may be required. Start with 100 mg.
Renal_impairment
Use with caution. Reduced dose may be necessary.
How to Take
Take orally with or without food.
Mechanism of Action
The exact mechanism of action of modafinil is unknown. It is thought to increase dopamine levels in the brain by blocking the dopamine transporter.
Pharmacokinetics
Onset
Effects typically begin within 30-60 minutes.
Excretion
Excreted mainly in the urine.
Half life
12-15 hours.
Absorption
Rapidly absorbed after oral administration.
Metabolism
Primarily hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to modafinil
- Uncontrolled hypertension
Drug Interactions
CYP3A4/5 Substrates
Modafinil can induce CYP3A4/5 enzymes, potentially altering the metabolism of other drugs.
Oral Contraceptives
Modafinil may decrease the effectiveness of hormonal contraceptives.
Storage
Store at room temperature, away from moisture and heat.
Overdose
Symptoms of overdose may include agitation, insomnia, confusion, anxiety, hallucinations, and gastrointestinal disturbances. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Caution should be exercised when used during lactation.
Side Effects
Contraindications
- Hypersensitivity to modafinil
- Uncontrolled hypertension
Drug Interactions
CYP3A4/5 Substrates
Modafinil can induce CYP3A4/5 enzymes, potentially altering the metabolism of other drugs.
Oral Contraceptives
Modafinil may decrease the effectiveness of hormonal contraceptives.
Storage
Store at room temperature, away from moisture and heat.
Overdose
Symptoms of overdose may include agitation, insomnia, confusion, anxiety, hallucinations, and gastrointestinal disturbances. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Caution should be exercised when used during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies and hospitals
Approval Status
FDA Approved, DGDA Approved
Patent Status
Expired
Clinical Trials
Several clinical trials have demonstrated the effectiveness of modafinil for various sleep disorders.
Lab Monitoring
- Liver function tests
- Blood pressure monitoring
Doctor Notes
- Assess patients for cardiovascular risk factors before initiating modafinil.
- Monitor blood pressure regularly.
Patient Guidelines
- Take as prescribed.
- Avoid alcohol.
- Report any unusual side effects.
Missed Dose Advice
Take the missed dose as soon as you remember it. Skip the missed dose if it is almost time for your next scheduled dose.
Driving Precautions
Modafinil may impair your ability to drive or operate machinery. Use caution until you know how it affects you.
Lifestyle Advice
- Maintain a regular sleep schedule.
- Avoid caffeine close to bedtime.
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Global Brand Names
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