Analpain
Generic Name
Paracetamol
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| analpain 500 mg tablet | ৳ 1.25 | N/A |
Description
Overview of the medicine
Analpain 500 mg Tablet contains Paracetamol, which is a widely used medication for relieving mild to moderate pain and reducing fever. It works by inhibiting prostaglandin synthesis in the central nervous system.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg (1-2 tablets) every 4-6 hours as needed. Maximum 4000 mg (8 tablets) in 24 hours.
Elderly
No specific dose reduction required, but caution is advised in frail elderly or those with impaired hepatic/renal function.
Renal_impairment
Dose adjustment may be necessary in severe renal impairment (creatinine clearance <10 mL/min). Interval prolongation to 6-8 hours.
How to Take
Take orally with or without food. Do not crush or chew the tablet. For best absorption, it can be taken on an empty stomach, but taking with food may reduce gastric upset.
Mechanism of Action
Paracetamol is thought to primarily act in the central nervous system by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, leading to reduced prostaglandin synthesis. This results in analgesic (pain-relieving) and antipyretic (fever-reducing) effects. Its peripheral anti-inflammatory activity is minimal.
Pharmacokinetics
Onset
Within 30-60 minutes for pain relief, longer for fever reduction.
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
1.5 to 3 hours (adults); slightly shorter in children, longer in neonates and in hepatic dysfunction.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30 to 60 minutes after oral administration.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation. A small portion is metabolized by cytochrome P450 to a highly reactive intermediate (N-acetyl-p-benzoquinone imine or NAPQI), which is detoxified by conjugation with glutathione.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increased risk of hepatotoxicity with chronic excessive alcohol intake.
Warfarin and other coumarins
May enhance anticoagulant effect with prolonged regular daily use, increasing bleeding risk.
Phenobarbital, Phenytoin, Carbamazepine
May increase the risk of hepatotoxicity.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, anorexia, and malaise. Severe overdose can lead to acute liver failure (hepatotoxicity), renal tubular necrosis, and coma. Treatment involves gastric decontamination (if recent) and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use during all trimesters of pregnancy at recommended doses, but always consult a doctor. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding at recommended doses.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Pharmacies, supermarkets, general stores
Approval Status
Approved (Widely available OTC)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Paracetamol has been extensively studied for decades, demonstrating its efficacy and safety profile in numerous clinical trials for pain and fever management. Recent studies continue to explore its mechanisms and optimal use.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) in cases of overdose or prolonged high-dose therapy.
- Renal function tests if long-term high-dose use or pre-existing renal impairment.
Doctor Notes
- Advise patients on the importance of not exceeding the maximum daily dose (4g for adults) due to the risk of severe hepatotoxicity.
- Counsel patients to identify and avoid concomitant use of other Paracetamol-containing medications.
- Exercise caution in patients with pre-existing hepatic or renal impairment, chronic alcoholism, or severe malnutrition.
Patient Guidelines
- Do not exceed the recommended dose. Taking more than recommended can cause serious liver damage.
- Do not take with other Paracetamol-containing products.
- Consult a doctor if pain or fever persists for more than a few days, or if new symptoms appear.
- Avoid alcohol consumption during treatment, especially with prolonged use.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Analpain 500 mg Tablet generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or drowsiness, avoid these activities.
Lifestyle Advice
- Ensure adequate hydration, especially during fever.
- Get sufficient rest to aid recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.