Anastrol
Generic Name
Anastrozole 1 mg tablet
Manufacturer
Various (e.g., Square Pharmaceuticals Ltd., Incepta Pharmaceuticals Ltd. in Bangladesh)
Country
Various
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| anastrol 1 mg tablet | ৳ 50.00 | ৳ 500.00 |
Description
Overview of the medicine
Anastrol 1 mg tablet contains Anastrozole, a potent and selective non-steroidal aromatase inhibitor. It is used in the treatment of hormone receptor-positive early and advanced breast cancer in postmenopausal women.
Uses & Indications
Dosage
Adults
1 mg orally once daily.
Elderly
No dosage adjustment required.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Taken orally, with or without food, at approximately the same time each day.
Mechanism of Action
Anastrozole selectively inhibits aromatase, an enzyme that converts androgens into estrogens. By reducing estrogen levels, it slows the growth of hormone-sensitive breast cancer cells.
Pharmacokinetics
Onset
Significant estrogen suppression within 24 hours.
Excretion
About 10% excreted unchanged in urine; metabolites are excreted renally.
Half life
Approximately 40-50 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, peak plasma concentrations usually achieved within 2 hours.
Metabolism
Primarily hepatic metabolism via N-dealkylation, hydroxylation, and glucuronidation.
Side Effects
Contraindications
- Pre-menopausal women.
- Pregnant or lactating women.
- Patients with known hypersensitivity to anastrozole or any component of the tablet.
Drug Interactions
Tamoxifen
Concomitant use with tamoxifen or other estrogen-containing therapies should be avoided as it may reduce the pharmacological action of anastrozole.
Estrogen-containing therapies
Avoid concurrent use.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Contraindicated in pregnancy and lactation. May cause fetal harm and is unknown if excreted in breast milk.
Side Effects
Contraindications
- Pre-menopausal women.
- Pregnant or lactating women.
- Patients with known hypersensitivity to anastrozole or any component of the tablet.
Drug Interactions
Tamoxifen
Concomitant use with tamoxifen or other estrogen-containing therapies should be avoided as it may reduce the pharmacological action of anastrozole.
Estrogen-containing therapies
Avoid concurrent use.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Contraindicated in pregnancy and lactation. May cause fetal harm and is unknown if excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, as specified by the manufacturer.
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials (e.g., ATAC trial) have demonstrated its efficacy and safety in early and advanced breast cancer.
Lab Monitoring
- Bone mineral density (due to risk of osteoporosis)
- Lipid profile
- Liver function tests (periodically)
Doctor Notes
- Monitor bone mineral density and lipid profile regularly.
- Consider calcium and vitamin D supplementation.
- Advise patients on lifestyle modifications to support bone health.
Patient Guidelines
- Take as directed by your doctor, do not stop without consultation.
- Report any new or worsening symptoms.
- Regular bone density scans may be advised.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose.
Driving Precautions
May cause fatigue, dizziness, or somnolence. Patients should be cautioned about driving or operating machinery if they experience these symptoms.
Lifestyle Advice
- Maintain a healthy diet rich in calcium and vitamin D.
- Engage in regular weight-bearing exercise to support bone health.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.