Ancipro
Generic Name
Ciprofloxacin 500 mg Tablet
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ancipro 500 mg tablet | ৳ 14.00 | ৳ 140.00 |
Description
Overview of the medicine
Ancipro 500 mg Tablet contains Ciprofloxacin, a fluoroquinolone antibiotic used to treat various bacterial infections including urinary tract infections, respiratory tract infections, skin and soft tissue infections, bone and joint infections, and infectious diarrhea.
Uses & Indications
Dosage
Adults
The usual adult dose for most infections is 500 mg orally twice daily. Dosage may vary depending on the severity and type of infection, ranging from 250 mg to 750 mg twice daily. Duration of treatment depends on the infection.
Elderly
No specific dose adjustment is needed based solely on age, but renal function should be assessed, and dosage adjusted accordingly.
Renal_impairment
Dosage adjustment is necessary for patients with impaired renal function. For creatinine clearance between 30-60 mL/min, 250-500 mg every 12 hours. For <30 mL/min, 250-500 mg every 18-24 hours.
How to Take
Take Ancipro 500 mg Tablet orally, with or without food. However, to minimize potential gastrointestinal upset, it can be taken with food. Avoid taking it with dairy products (milk, yogurt) or calcium-fortified juices, as these can reduce absorption. Also, take it at least 2 hours before or 6 hours after antacids, iron, or zinc supplements.
Mechanism of Action
Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.
Pharmacokinetics
Onset
Significant plasma levels observed within 1-2 hours of oral administration.
Excretion
Primarily renal, with approximately 50-70% of an oral dose excreted unchanged in the urine. A smaller portion is eliminated via the feces.
Half life
Approximately 3-5 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract, with bioavailability of approximately 70-80%. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Undergoes limited hepatic metabolism (approximately 15-30%) via CYP450 enzymes to form less active metabolites.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other fluoroquinolones.
- Concomitant administration with tizanidine.
- Children and adolescents (except in specific conditions like complicated UTIs, anthrax, or cystic fibrosis).
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and convulsive seizures.
Warfarin
May enhance the anticoagulant effect of warfarin, requiring INR monitoring.
Tizanidine
Concomitant use is contraindicated due to increased tizanidine levels, leading to hypotension and sedation.
Theophylline
Ciprofloxacin can increase theophylline levels, leading to toxicity. Monitor theophylline levels.
Antacids/Iron/Zinc
Can reduce ciprofloxacin absorption. Administer at least 2 hours before or 6 hours after.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic and supportive treatment should be initiated. Acute overdosage symptoms may include renal toxicity. Gastric lavage and induced emesis may be considered if recent. Hydration is important to prevent crystalluria.
Pregnancy & Lactation
Pregnancy Category C. Ciprofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk and is generally not recommended for use during breastfeeding due to the risk of arthropathy in infants.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other fluoroquinolones.
- Concomitant administration with tizanidine.
- Children and adolescents (except in specific conditions like complicated UTIs, anthrax, or cystic fibrosis).
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and convulsive seizures.
Warfarin
May enhance the anticoagulant effect of warfarin, requiring INR monitoring.
Tizanidine
Concomitant use is contraindicated due to increased tizanidine levels, leading to hypotension and sedation.
Theophylline
Ciprofloxacin can increase theophylline levels, leading to toxicity. Monitor theophylline levels.
Antacids/Iron/Zinc
Can reduce ciprofloxacin absorption. Administer at least 2 hours before or 6 hours after.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic and supportive treatment should be initiated. Acute overdosage symptoms may include renal toxicity. Gastric lavage and induced emesis may be considered if recent. Hydration is important to prevent crystalluria.
Pregnancy & Lactation
Pregnancy Category C. Ciprofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk and is generally not recommended for use during breastfeeding due to the risk of arthropathy in infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
FDA approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Ciprofloxacin has undergone extensive clinical trials demonstrating its efficacy and safety across various indications. Ongoing post-marketing surveillance and studies continue to refine its use.
Lab Monitoring
- Renal function tests (especially in elderly or renally impaired patients)
- Liver function tests (with prolonged therapy)
- Complete blood count (CBC) (with prolonged therapy)
- Serum theophylline levels (if co-administered with theophylline)
Doctor Notes
- Assess renal function before initiating and during treatment, especially in elderly patients.
- Counsel patients on the Black Box Warning risks, including tendinopathy, peripheral neuropathy, and CNS effects.
- Avoid concomitant use with tizanidine due to severe hypotensive risk.
- Monitor for C. difficile infection if severe diarrhea develops.
- Caution in patients with a history of seizures or other CNS disorders.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Drink plenty of fluids to prevent crystalluria.
- Avoid excessive exposure to sunlight or artificial UV light due to photosensitivity.
- Report any new or worsening tendon pain, numbness, tingling, or weakness immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Ciprofloxacin may cause dizziness, lightheadedness, or visual disturbances. Patients should be advised to know how they react to ciprofloxacin before driving or operating machinery.
Lifestyle Advice
- Stay well-hydrated throughout the treatment period.
- Avoid or limit caffeine intake, as ciprofloxacin can increase caffeine levels and its effects.
- Avoid driving or operating machinery if you experience dizziness or lightheadedness.
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