Ancotil
Generic Name
Flucytosine
Manufacturer
Mylan Pharmaceuticals
Country
United States
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ancotil 3 mg tablet | ৳ 4.02 | ৳ 40.20 |
Description
Overview of the medicine
Ancotil (Flucytosine) is an antifungal medication used to treat serious fungal infections.
Uses & Indications
Dosage
Adults
50-150 mg/kg/day divided into 4 doses, administered every 6 hours.
Elderly
Lower doses may be required due to decreased renal function.
Renal_impairment
Dosage adjustments are required based on creatinine clearance.
How to Take
Administer orally with or without food. IV administration requires trained personnel.
Mechanism of Action
Flucytosine is converted into fluorouracil within fungal cells, which inhibits DNA and RNA synthesis.
Pharmacokinetics
Onset
Variable, depending on the fungal infection.
Excretion
Primarily renal excretion.
Half life
3-6 hours in patients with normal renal function.
Absorption
Rapidly and well absorbed from the gastrointestinal tract.
Metabolism
Deamination in the liver and GI tract.
Side Effects
Contraindications
- Hypersensitivity to flucytosine
- Severe renal impairment without close monitoring
Drug Interactions
Cytosine
May reduce the effectiveness of flucytosine.
Amphotericin B
May increase flucytosine toxicity.
Storage
Store at room temperature (20-25°C). Protect from light and moisture.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, and bone marrow suppression. Treatment is supportive.
Pregnancy & Lactation
Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administering flucytosine to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies and hospitals
Approval Status
FDA Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Clinical trials have demonstrated the efficacy of flucytosine in treating various fungal infections.
Lab Monitoring
- Complete blood count
- Renal function tests
- Liver function tests
Doctor Notes
- Monitor renal function closely during treatment.
- Consider combination therapy with amphotericin B for severe infections.
Patient Guidelines
- Take the medication exactly as prescribed.
- Report any unusual bleeding or bruising to your doctor.
- Attend all scheduled follow-up appointments.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
Driving Precautions
Use caution while driving or operating machinery as flucytosine may cause dizziness.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.