Anosea-Plus
Generic Name
Anosea-plus 25 mg tablet
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| anosea plus 25 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Anosea-Plus 25 mg Tablet is a combination medication containing Meclizine, an antihistamine, and Pyridoxine (Vitamin B6). It is primarily used to relieve symptoms of nausea, vomiting, and dizziness, especially associated with motion sickness, vertigo, and morning sickness during pregnancy.
Uses & Indications
Dosage
Adults
For nausea/vomiting/vertigo: 1-2 tablets daily, or as directed by physician. For motion sickness: 1-2 tablets one hour before travel, then 1 tablet daily if needed.
Elderly
Use with caution due to increased risk of anticholinergic side effects. Dosage may need adjustment based on individual response and renal function.
Renal_impairment
No specific dose adjustment for mild to moderate renal impairment, but caution is advised. Avoid in severe impairment.
How to Take
Take orally with water, with or without food. For motion sickness, take at least one hour before travel.
Mechanism of Action
Meclizine acts by blocking H1 histamine receptors, particularly in the brainstem, which helps to inhibit vestibular stimulation and reduce motion sickness and vertigo. It also has anticholinergic effects. Pyridoxine's exact anti-emetic mechanism is not fully understood but is thought to involve influencing central neurotransmitter synthesis, particularly GABA and serotonin, which can alleviate nausea.
Pharmacokinetics
Onset
Meclizine: Approximately 1 hour for anti-emetic effects. Pyridoxine: Variable, usually within hours.
Excretion
Meclizine is primarily excreted in feces as unchanged drug and metabolites; some renal excretion. Pyridoxine and its metabolites are excreted renally.
Half life
Meclizine: 6-10 hours. Pyridoxine: 15-20 days (for phosphorylated forms)
Absorption
Meclizine is slowly but well absorbed from the gastrointestinal tract. Pyridoxine is readily absorbed, primarily in the jejunum.
Metabolism
Meclizine is metabolized in the liver, likely via CYP2D6. Pyridoxine is metabolized in the liver to its active forms (pyridoxal phosphate).
Side Effects
Contraindications
- Hypersensitivity to meclizine, pyridoxine, or any component of the formulation
- Acute asthma attacks
- Narrow-angle glaucoma
- Prostatic hypertrophy with urinary retention
Drug Interactions
MAO Inhibitors
May prolong and intensify the anticholinergic effects of meclizine.
CNS Depressants (e.g., alcohol, sedatives, tranquilizers)
May enhance the sedative effects of meclizine.
Anticholinergic drugs (e.g., tricyclic antidepressants, atropine)
May potentiate anticholinergic side effects like dry mouth, blurred vision, urinary retention.
Storage
Store in a cool (below 30°C) and dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, confusion, blurred vision, dry mouth, urinary retention, dilated pupils, agitation, hallucinations, and seizures. Management involves supportive care, gastric lavage if recent ingestion, and symptomatic treatment.
Pregnancy & Lactation
Meclizine and Pyridoxine are generally considered safe for use during pregnancy (Category B), particularly for morning sickness. Small amounts of meclizine may pass into breast milk; use during lactation should be done with caution and under medical supervision.
Side Effects
Contraindications
- Hypersensitivity to meclizine, pyridoxine, or any component of the formulation
- Acute asthma attacks
- Narrow-angle glaucoma
- Prostatic hypertrophy with urinary retention
Drug Interactions
MAO Inhibitors
May prolong and intensify the anticholinergic effects of meclizine.
CNS Depressants (e.g., alcohol, sedatives, tranquilizers)
May enhance the sedative effects of meclizine.
Anticholinergic drugs (e.g., tricyclic antidepressants, atropine)
May potentiate anticholinergic side effects like dry mouth, blurred vision, urinary retention.
Storage
Store in a cool (below 30°C) and dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, confusion, blurred vision, dry mouth, urinary retention, dilated pupils, agitation, hallucinations, and seizures. Management involves supportive care, gastric lavage if recent ingestion, and symptomatic treatment.
Pregnancy & Lactation
Meclizine and Pyridoxine are generally considered safe for use during pregnancy (Category B), particularly for morning sickness. Small amounts of meclizine may pass into breast milk; use during lactation should be done with caution and under medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies
Approval Status
Locally registered. Not a globally standardized generic name.
Patent Status
Generic/Off-patent for active ingredients
Clinical Trials
Clinical trials for meclizine and pyridoxine, both individually and in combination, have demonstrated efficacy in managing nausea, vomiting, and dizziness, particularly in specific patient populations like pregnant women and those with motion sickness.
Lab Monitoring
- Routine lab monitoring is not typically required for healthy individuals. Patients with pre-existing conditions (e.g., glaucoma, prostatic hypertrophy) may require closer monitoring.
Doctor Notes
- Assess patient's risk for sedation and anticholinergic effects, especially in the elderly.
- Counsel patients on avoiding alcohol and activities requiring alertness.
- Consider alternative therapies if symptoms persist or side effects are intolerable.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Avoid driving or operating heavy machinery if you experience drowsiness.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause drowsiness or blurred vision. Do not drive or engage in activities requiring mental alertness until you know how it affects you.
Lifestyle Advice
- Stay well-hydrated, especially if experiencing vomiting.
- Rest adequately to help manage symptoms.
- Avoid alcohol while taking this medication.
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Global Brand Names
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