Antanil
Generic Name
Mebendazole
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| antanil 200 mg suspension | ৳ 45.00 | N/A |
Description
Overview of the medicine
Antanil 200 mg Suspension is an anthelmintic medication containing Mebendazole, used to treat various parasitic worm infections such as pinworm, roundworm, whipworm, and hookworm. It works by preventing the worms from absorbing sugar (glucose), which leads to the depletion of their energy stores and eventually their death.
Uses & Indications
Dosage
Adults
Pinworm: 200 mg single dose. Repeat in 2-4 weeks if necessary. Other infections (roundworm, whipworm, hookworm, mixed): 200 mg twice daily for 3 consecutive days.
Elderly
Same as adult dosage. No specific dose adjustment generally required, but caution with severe hepatic impairment.
Renal_impairment
No dosage adjustment needed for renal impairment as systemic absorption is minimal and excretion is primarily fecal.
How to Take
Shake well before use. The suspension can be taken with or without food. For better absorption, it can be taken with a fatty meal. No special diet or fasting is necessary.
Mechanism of Action
Mebendazole selectively and irreversibly blocks glucose uptake and other nutrients in susceptible helminths, leading to the depletion of glycogen stores. This results in decreased ATP formation, immobilization, and ultimately the death of the parasite. It primarily acts on the intestinal lumen.
Pharmacokinetics
Onset
Effects on worms begin within hours, but complete parasite clearance may take several days to weeks depending on the infection.
Excretion
The majority (approximately 90%) of the administered dose is excreted unchanged in the feces. A small portion of absorbed drug and its metabolites are excreted in the urine.
Half life
Plasma half-life is typically 2.5 to 5.5 hours. For its active metabolite (hydrolyzed mebendazole), it can be up to 10-15 hours.
Absorption
Poorly absorbed from the gastrointestinal tract (approximately 5-10%). Absorption can be increased when taken with a fatty meal.
Metabolism
Extensively metabolized in the liver, primarily by hydrolysis. The main metabolite is 2-amino-5(6)-benzimidazolyl carbamate.
Side Effects
Contraindications
- Hypersensitivity to Mebendazole or any component of the formulation
- Children under 2 years of age (due to potential for convulsions)
Drug Interactions
Cimetidine
May increase plasma concentration of Mebendazole by inhibiting its metabolism, leading to increased systemic exposure.
Metronidazole
Concurrent use with Mebendazole has been reported to be associated with an increased risk of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).
Phenytoin, Carbamazepine
May decrease plasma concentration of Mebendazole due to induction of hepatic metabolism, potentially reducing its efficacy.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastrointestinal symptoms (abdominal pain, nausea, vomiting, diarrhea) may occur. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal if overdose is recent.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. It is recommended to avoid use during the first trimester. Mebendazole is minimally excreted in human milk; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to Mebendazole or any component of the formulation
- Children under 2 years of age (due to potential for convulsions)
Drug Interactions
Cimetidine
May increase plasma concentration of Mebendazole by inhibiting its metabolism, leading to increased systemic exposure.
Metronidazole
Concurrent use with Mebendazole has been reported to be associated with an increased risk of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).
Phenytoin, Carbamazepine
May decrease plasma concentration of Mebendazole due to induction of hepatic metabolism, potentially reducing its efficacy.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastrointestinal symptoms (abdominal pain, nausea, vomiting, diarrhea) may occur. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal if overdose is recent.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. It is recommended to avoid use during the first trimester. Mebendazole is minimally excreted in human milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date (check product label)
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Mebendazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for various helminthic infections. Ongoing research explores its potential in oncology due to its anti-cancer properties.
Lab Monitoring
- Liver function tests (for prolonged high-dose therapy or systemic infections)
- Complete blood count (for prolonged high-dose therapy or systemic infections)
Doctor Notes
- Advise patients on proper hygiene to prevent reinfection.
- Consider treating all household members simultaneously for pinworm infections.
- Monitor liver function and CBC for prolonged therapy.
- Caution in children under 2 years.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Wash hands thoroughly before meals and after using the toilet.
- Trim fingernails short to prevent reinfection.
- Regular deworming for the whole family may be recommended.
- Consult a doctor if symptoms persist or worsen.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Mebendazole generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or other central nervous system effects, avoid such activities.
Lifestyle Advice
- Maintain good personal hygiene to prevent reinfection.
- Ensure clean drinking water and food preparation.
- Avoid walking barefoot in endemic areas.
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