Antima
Generic Name
Albendazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| antima 100 mg suspension | ৳ 220.00 | N/A |
Description
Overview of the medicine
Antima 100 mg Suspension contains Albendazole, an anthelmintic medication used to treat various parasitic worm infections in humans.
Uses & Indications
Dosage
Adults
For children 2 years and above and adults: For Ascariasis, Trichuriasis, Hookworm, Enterobiasis: 400 mg (e.g., two 100 mg suspensions or one 400 mg tablet) as a single dose. For children 1-2 years: 200 mg (e.g., one 100 mg suspension taken twice or one 200 mg suspension) as a single dose.
Elderly
Dosage adjustment not generally required for elderly unless significant hepatic or renal impairment is present.
Renal_impairment
No dosage adjustment necessary for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Shake well before use. Can be taken with or without food, but taking with a fatty meal significantly increases absorption for systemic infections. For intestinal infections, food intake is less critical but still recommended.
Mechanism of Action
Albendazole acts by inhibiting the polymerization of beta-tubulin, leading to the disruption of parasite motility and glucose uptake, ultimately causing the worm's death.
Pharmacokinetics
Onset
Not well defined; clinical effects are usually observed within a few days to weeks depending on the infection.
Excretion
Primarily excreted in the bile; a small amount is excreted in urine as metabolites.
Half life
Approximately 8-12 hours for the active metabolite, albendazole sulfoxide.
Absorption
Poorly absorbed from the gastrointestinal tract; absorption is significantly increased with a fatty meal.
Metabolism
Extensively metabolized in the liver to the primary active metabolite, albendazole sulfoxide.
Side Effects
Contraindications
- Hypersensitivity to albendazole or any component of the suspension
- Pregnancy (especially first trimester)
Drug Interactions
Cimetidine
Increases plasma concentrations of albendazole sulfoxide.
Praziquantel
Increases plasma concentrations of albendazole sulfoxide.
Theophylline
Albendazole may decrease theophylline clearance.
Dexamethasone
Increases plasma concentrations of albendazole sulfoxide.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose may include gastrointestinal disturbances, headache, dizziness, and liver enzyme elevation. Treatment is symptomatic and supportive; gastric lavage may be considered.
Pregnancy & Lactation
Albendazole is contraindicated during pregnancy, particularly in the first trimester, due to potential teratogenic effects. Women of childbearing potential should use effective contraception during and for at least one month after treatment. Use during lactation is generally discouraged; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date, check packaging for exact details.
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Albendazole has undergone extensive clinical trials demonstrating its efficacy and safety in treating various helminthic infections. Ongoing research explores its potential in other parasitic diseases and certain cancers.
Lab Monitoring
- Liver function tests (especially for long-term treatment)
- Complete blood count (for long-term treatment)
- Stool examination for ova and parasites
Doctor Notes
- Advise patients to complete the entire course of treatment.
- For systemic infections, administer with a fatty meal to enhance absorption.
- Monitor liver enzymes and CBC for prolonged therapy.
- Contraindicated in pregnancy.
Patient Guidelines
- Take the full course of medication as prescribed, even if symptoms improve.
- Inform your doctor about all other medications you are taking.
- Report any severe or persistent side effects to your doctor.
- Maintain good hygiene to prevent reinfection.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Albendazole may cause dizziness or lightheadedness in some individuals. If you experience these symptoms, avoid driving or operating heavy machinery.
Lifestyle Advice
- Wash hands thoroughly before meals and after using the toilet.
- Ensure proper sanitation and hygiene at home.
- Avoid consuming raw or undercooked meat.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.