Apnac 50 mg Tablet should be swallowed whole with sufficient liquid, preferably with or after food, to minimize gastrointestinal discomfort.

Aceclofenac exerts its anti-inflammatory and analgesic effects by inhibiting the enzyme cyclooxygenase (COX), which is involved in the synthesis of prostaglandins. Prostaglandins are mediators of inflammation, pain, and fever.

• •Hypersensitivity to Aceclofenac or any other NSAID (e.g., aspirin)
• •Patients with active gastrointestinal bleeding or peptic ulceration
• •Severe renal or hepatic impairment
• •Severe heart failure
• •Third trimester of pregnancy
• •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Symptoms of overdose may include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, diarrhea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, and convulsions. In cases of significant poisoning, acute renal failure and liver damage are possible. Treatment is symptomatic and supportive, including gastric emptying (e.g., activated charcoal or gastric lavage) within one hour of ingestion. Monitor vital signs and renal function.

Aceclofenac is contraindicated in the third trimester of pregnancy due to potential risks to the fetus (e.g., premature closure of the ductus arteriosus). In the first and second trimesters, it should be used only if the potential benefit outweighs the potential risk. Aceclofenac is excreted in human milk in small amounts; therefore, it is generally not recommended during breastfeeding.