Appras
Generic Name
Aripiprazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| appras 5 mg tablet | ৳ 14.00 | ৳ 140.00 |
Description
Overview of the medicine
Appras 5 mg Tablet contains Aripiprazole, an atypical antipsychotic used to treat schizophrenia, bipolar I disorder, and as an adjunctive treatment for major depressive disorder. It helps to restore the balance of certain natural substances in the brain.
Uses & Indications
Dosage
Adults
Initial dose 10-15 mg once daily; target range 10-30 mg once daily. For adjunctive MDD, initial 2-5 mg, target 5-15 mg.
Elderly
No specific dosage adjustment based on age alone; use with caution due to potential for orthostatic hypotension and increased sensitivity.
Renal_impairment
No dosage adjustment required in patients with renal impairment.
How to Take
Take orally once daily, with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Aripiprazole is thought to work as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors and as an antagonist at serotonin 5-HT2A receptors. This unique profile helps to stabilize dopamine and serotonin systems in the brain.
Pharmacokinetics
Onset
Clinical improvement may be observed within 1-2 weeks, but full therapeutic effect may take several weeks.
Excretion
Excreted in urine (approx. 27%) and feces (approx. 60%), primarily as metabolites.
Half life
Approximately 75 hours for aripiprazole and 94 hours for its active metabolite, dehydro-aripiprazole.
Absorption
Well absorbed after oral administration, peak plasma concentrations typically occur within 3-5 hours.
Metabolism
Extensively metabolized by cytochrome P450 enzymes, primarily CYP2D6 and CYP3A4, to its active metabolite, dehydro-aripiprazole.
Side Effects
Contraindications
- •Hypersensitivity to aripiprazole or any component of the formulation.
- •Severe cardiac conditions (relative contraindication, use with caution).
Drug Interactions
Antihypertensives
May enhance hypotensive effects.
CYP3A4 inducers (e.g., Carbamazepine)
May decrease aripiprazole levels; dose increase may be necessary.
CYP3A4 inhibitors (e.g., Ketoconazole)
May increase aripiprazole levels; dose reduction may be necessary.
CYP2D6 inhibitors (e.g., Quinidine, Fluoxetine)
May increase aripiprazole levels; dose reduction may be necessary.
Central Nervous System (CNS) depressants (e.g., alcohol, benzodiazepines)
May potentiate CNS depressant effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, vomiting, tremor, and tachycardia. Management is primarily supportive, with maintenance of an adequate airway, oxygenation, and ventilation. Monitor cardiac rhythm and vital signs.
Pregnancy & Lactation
Category C in pregnancy. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies worldwide
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generics available (original patent expired)
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Global Brand Names
International brand names for this medicine
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