Apremig ODT
Generic Name
Apremilast Orally Disintegrating Tablet
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| apremig odt 75 mg tablet | ৳ 150.00 | ৳ 600.00 |
Description
Overview of the medicine
Apremig ODT is a phosphodiesterase 4 (PDE4) inhibitor used for the treatment of psoriasis and psoriatic arthritis.
Uses & Indications
Dosage
Adults
30 mg twice daily, starting with a titration schedule (10 mg once daily on day 1, 10 mg twice daily on day 2, 20 mg once daily on day 3, 20 mg twice daily on day 4, 30 mg once daily on day 5, and 30 mg twice daily from day 6 onwards).
Elderly
No specific dosage adjustment is required for elderly patients.
Renal_impairment
In patients with severe renal impairment (CrCl <30 mL/min), the dosage should be reduced to 30 mg once daily.
How to Take
Place the tablet in the mouth and allow it to disintegrate. Can be taken with or without food.
Mechanism of Action
Apremilast works by inhibiting PDE4, an enzyme that controls the production of inflammatory mediators within cells.
Pharmacokinetics
Onset
Clinical effect typically observed within 2-4 weeks.
Excretion
Approximately 58% excreted in the feces and 39% in the urine.
Half life
Approximately 6-9 hours.
Absorption
Rapidly absorbed after oral administration. Food does not significantly affect absorption.
Metabolism
Metabolized primarily by CYP3A4, with minor contributions from CYP1A2 and CYP2A6.
Side Effects
Contraindications
- Known hypersensitivity to apremilast or any of the excipients.
- Pregnancy
Drug Interactions
Methotrexate
No significant drug interaction observed, but monitor for potential additive immunosuppressive effects.
Strong CYP3A4 inducers (e.g., rifampin, phenytoin, carbamazepine)
May decrease apremilast exposure and reduce efficacy. Avoid concomitant use.
Storage
Store below 30°C, protect from light and moisture.
Overdose
In case of overdose, provide supportive and symptomatic treatment.
Pregnancy & Lactation
Apremilast is contraindicated during pregnancy. It is not known whether apremilast is excreted in human milk; therefore, caution should be exercised when administering apremilast to a nursing woman.
Side Effects
Contraindications
- Known hypersensitivity to apremilast or any of the excipients.
- Pregnancy
Drug Interactions
Methotrexate
No significant drug interaction observed, but monitor for potential additive immunosuppressive effects.
Strong CYP3A4 inducers (e.g., rifampin, phenytoin, carbamazepine)
May decrease apremilast exposure and reduce efficacy. Avoid concomitant use.
Storage
Store below 30°C, protect from light and moisture.
Overdose
In case of overdose, provide supportive and symptomatic treatment.
Pregnancy & Lactation
Apremilast is contraindicated during pregnancy. It is not known whether apremilast is excreted in human milk; therefore, caution should be exercised when administering apremilast to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies and hospitals
Approval Status
FDA Approved, DGDA Approved
Patent Status
Patent Protected
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Apremilast in the treatment of psoriasis and psoriatic arthritis.
Lab Monitoring
- Liver function tests (periodically)
- CBC (periodically)
Doctor Notes
- Monitor patients for signs and symptoms of depression or suicidal ideation.
- Consider dose reduction in patients with severe renal impairment.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Report any unusual side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once.
Driving Precautions
Apremilast is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or fatigue, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet and exercise regularly.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.