Apridex
Generic Name
Pantoprazole
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| apridex 40 mg capsule | ৳ 50.00 | ৳ 250.00 |
Description
Overview of the medicine
Pantoprazole is a proton pump inhibitor used to treat conditions where stomach acid needs to be reduced, such as GERD, peptic ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
Erosive Esophagitis: 40 mg once daily for up to 8 weeks. Zollinger-Ellison: 40-80 mg twice daily.
Elderly
No specific dose adjustment generally needed, but monitor for adverse effects.
Renal_impairment
No dose adjustment required.
How to Take
Take orally, preferably 30-60 minutes before a meal. Swallow whole, do not crush or chew.
Mechanism of Action
Pantoprazole irreversibly binds to the H+/K+-ATPase enzyme (proton pump) in the gastric parietal cells, inhibiting the final step of acid production.
Pharmacokinetics
Onset
Onset of acid suppression within 1 hour, full effect within 2-3 days.
Excretion
Primarily excreted in urine (approx. 80%) and feces (approx. 18%) as metabolites.
Half life
Approximately 1 hour.
Absorption
Rapidly absorbed after oral administration, bioavailability is about 77%. Peak plasma concentrations within 2-2.5 hours.
Metabolism
Extensively metabolized in the liver via cytochrome P450 (CYP) system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or other substituted benzimidazoles.
- Concomitant use with rilpivirine-containing products.
Drug Interactions
Warfarin
Increased INR/PT reported.
Clopidogrel
Possible reduced antiplatelet effect (clinical significance debated).
Methotrexate
Increased methotrexate levels.
Atazanavir, Nelfinavir, Rilpivirine
Reduced absorption, contraindicated.
Storage
Store below 30°C, protected from light and moisture.
Overdose
Symptoms are generally mild. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use only if clearly needed. Consult doctor. Small amounts excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or other substituted benzimidazoles.
- Concomitant use with rilpivirine-containing products.
Drug Interactions
Warfarin
Increased INR/PT reported.
Clopidogrel
Possible reduced antiplatelet effect (clinical significance debated).
Methotrexate
Increased methotrexate levels.
Atazanavir, Nelfinavir, Rilpivirine
Reduced absorption, contraindicated.
Storage
Store below 30°C, protected from light and moisture.
Overdose
Symptoms are generally mild. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use only if clearly needed. Consult doctor. Small amounts excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous trials support its efficacy and safety in acid-related disorders.
Lab Monitoring
- No routine lab monitoring required, but magnesium levels might be checked with long-term use.
Doctor Notes
- Consider alternative therapies for long-term use due to potential risks.
- Educate patients on proper administration and potential side effects.
Patient Guidelines
- Take as directed by your doctor.
- Do not crush or chew the capsule.
- Inform your doctor about all other medications you are taking.
- Seek medical attention for severe or persistent side effects.
Missed Dose Advice
Take the missed dose as soon as remembered, unless it is almost time for the next dose. Do not double the dose.
Driving Precautions
May cause dizziness, so caution is advised when driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods and beverages (e.g., spicy food, caffeine, alcohol) that worsen acid reflux.
- Elevate the head of the bed for nighttime GERD symptoms.
- Maintain a healthy weight.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.