aptofen
Generic Name
aptofen-1-mg-syrup
Manufacturer
Hypothetical Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aptofen 1 mg syrup | ৳ 40.00 | N/A |
Description
Overview of the medicine
Aptofen 1 mg Syrup is used primarily for the prophylaxis of migraine and cluster headaches, and also as an appetite stimulant in underweight patients. It contains the active ingredient aptofen (Pizotifen-like action) which works by blocking certain natural substances (histamine and serotonin) in the body.
Uses & Indications
Dosage
Adults
Migraine prophylaxis: Initially 0.5 mg at night, gradually increasing to 0.5-1.5 mg daily in divided doses or as a single night dose. Max 3 mg/day. Appetite stimulation: 0.5 mg three times daily.
Elderly
Start with lower doses, e.g., 0.5 mg once daily, and adjust cautiously based on response and tolerability.
Renal_impairment
Use with caution. Dosage reduction may be necessary in severe impairment. No specific guidelines, monitor for adverse effects.
How to Take
Orally. Can be taken with or without food. To minimize sedation, initial dose can be taken at bedtime.
Mechanism of Action
Aptofen (Pizotifen-like) acts as an antagonist at serotonin (5-HT1 and 5-HT2) and histamine (H1) receptors. Its antiserotonergic action is thought to be responsible for its migraine prophylactic effect, while its H1 antagonism and possibly other central effects contribute to its appetite stimulating properties.
Pharmacokinetics
Onset
Migraine prophylaxis: several weeks for full effect; Appetite stimulation: within days.
Excretion
Mainly excreted in urine, largely as metabolites.
Half life
Approximately 23 hours.
Absorption
Well absorbed from the gastrointestinal tract, peak plasma concentrations reached within 5-8 hours.
Metabolism
Extensively metabolized in the liver, primarily by N-glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to aptofen (Pizotifen) or any components of the syrup
- Acute angle-closure glaucoma
- Urinary retention
Drug Interactions
Antihypertensives
May enhance hypotensive effect.
Anticholinergic drugs
Potentiation of anticholinergic effects.
Monoamine Oxidase Inhibitors (MAOIs)
Potential for enhanced effects due to inhibition of metabolism.
CNS Depressants (alcohol, sedatives, hypnotics)
Increased sedative effect.
Storage
Store below 30°C in a cool, dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.
Overdose
Symptoms: Drowsiness, dizziness, dry mouth, nausea, confusion, tachycardia, hypotension. Management: Symptomatic and supportive treatment. Gastric lavage may be considered if recent ingestion. Monitor vital signs.
Pregnancy & Lactation
Pregnancy category B (animal studies show no risk, but human data limited). Use only if clearly needed and potential benefits outweigh risks. Not recommended during breastfeeding as it may pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to aptofen (Pizotifen) or any components of the syrup
- Acute angle-closure glaucoma
- Urinary retention
Drug Interactions
Antihypertensives
May enhance hypotensive effect.
Anticholinergic drugs
Potentiation of anticholinergic effects.
Monoamine Oxidase Inhibitors (MAOIs)
Potential for enhanced effects due to inhibition of metabolism.
CNS Depressants (alcohol, sedatives, hypnotics)
Increased sedative effect.
Storage
Store below 30°C in a cool, dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.
Overdose
Symptoms: Drowsiness, dizziness, dry mouth, nausea, confusion, tachycardia, hypotension. Management: Symptomatic and supportive treatment. Gastric lavage may be considered if recent ingestion. Monitor vital signs.
Pregnancy & Lactation
Pregnancy category B (animal studies show no risk, but human data limited). Use only if clearly needed and potential benefits outweigh risks. Not recommended during breastfeeding as it may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, refer to package for exact expiry.
Availability
Pharmacies, Hospitals
Approval Status
Approved in many countries for migraine prophylaxis and appetite stimulation
Patent Status
Generic available, patent expired
Clinical Trials
Pizotifen has been evaluated in numerous clinical trials for migraine prophylaxis and appetite stimulation, showing efficacy and a known safety profile.
Lab Monitoring
- Periodically monitor weight, especially in children and adolescents. Liver function tests may be considered in long-term therapy or in patients with hepatic impairment.
Doctor Notes
- Counsel patients on potential sedation and weight gain.
- Review indications and contraindications carefully, especially in pediatric and elderly populations.
- Emphasize gradual dose titration for migraine prophylaxis.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking abruptly without consulting your doctor.
- Avoid driving or operating machinery until you know how this medicine affects you due to potential drowsiness.
- Avoid alcohol consumption.
Missed Dose Advice
If a dose is missed, take it as soon as remembered unless it's almost time for the next dose. Do not double the dose.
Driving Precautions
May cause drowsiness and affect ability to drive or operate machinery. Exercise caution.
Lifestyle Advice
- Maintain a balanced diet.
- Engage in regular physical activity if indicated for weight management.
- Report any unusual side effects to your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.