Aquagest
Generic Name
Progesterone
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aquagest 25 mg injection | ৳ 70.00 | N/A |
Description
Overview of the medicine
Aquagest 25 mg Injection contains Progesterone, a naturally occurring steroid hormone that plays a crucial role in the menstrual cycle, pregnancy, and embryogenesis. It is used to treat various conditions related to progesterone deficiency.
Uses & Indications
Dosage
Adults
Dosage varies by indication. For luteal phase support, typically 25 mg daily to twice daily via intramuscular injection. For threatened miscarriage, 25-50 mg daily until symptoms subside.
Elderly
No specific dosage adjustment is generally required, but caution is advised in patients with hepatic or renal impairment.
Renal_impairment
Use with caution; specific dosage adjustments may be needed based on individual patient response and monitoring.
How to Take
Aquagest 25 mg Injection is administered via intramuscular injection. The injection site should be alternated to minimize local reactions.
Mechanism of Action
Progesterone acts on the uterus by converting the proliferative endometrium into a secretory endometrium, preparing it for implantation. It also helps in maintaining pregnancy by suppressing uterine contractions and promoting endometrial receptivity.
Pharmacokinetics
Onset
Within hours of administration, with sustained effects depending on the formulation.
Excretion
Excreted mainly through the urine (50-60%) and feces (10%) as metabolites.
Half life
Approximately 5-20 minutes for endogenous progesterone, but depot preparations like injections can provide prolonged action for hours to days.
Absorption
Rapidly absorbed after intramuscular administration. Peak plasma concentrations are reached within 2-6 hours.
Metabolism
Primarily metabolized in the liver to various glucuronide and sulfate conjugates.
Side Effects
Contraindications
- Known hypersensitivity to progesterone or any component of the injection
- Undiagnosed vaginal bleeding
- Known or suspected breast cancer or other hormone-sensitive cancers
- Active thrombophlebitis or thromboembolic disorders
- Severe hepatic dysfunction or disease
Drug Interactions
Ketoconazole, Itraconazole
May increase progesterone levels due to inhibition of hepatic enzymes.
Carbamazepine, Rifampicin, Phenytoin
May decrease progesterone efficacy due to induction of hepatic enzymes.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Overdose symptoms may include drowsiness, dizziness, and fatigue. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Progesterone is often essential for maintaining pregnancy and is considered safe for use during pregnancy when indicated. It is excreted in breast milk in small amounts, but generally considered compatible with breastfeeding at therapeutic doses.
Side Effects
Contraindications
- Known hypersensitivity to progesterone or any component of the injection
- Undiagnosed vaginal bleeding
- Known or suspected breast cancer or other hormone-sensitive cancers
- Active thrombophlebitis or thromboembolic disorders
- Severe hepatic dysfunction or disease
Drug Interactions
Ketoconazole, Itraconazole
May increase progesterone levels due to inhibition of hepatic enzymes.
Carbamazepine, Rifampicin, Phenytoin
May decrease progesterone efficacy due to induction of hepatic enzymes.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Overdose symptoms may include drowsiness, dizziness, and fatigue. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Progesterone is often essential for maintaining pregnancy and is considered safe for use during pregnancy when indicated. It is excreted in breast milk in small amounts, but generally considered compatible with breastfeeding at therapeutic doses.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved (country specific)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of progesterone for its approved indications, especially in reproductive medicine.
Lab Monitoring
- Liver function tests (periodically, especially with long-term use)
- Blood glucose (for diabetic patients)
Doctor Notes
- Ensure correct administration technique for intramuscular injection.
- Monitor patients for signs of fluid retention or thromboembolic events.
- Advise patients on potential mood changes and to report severe depression.
Patient Guidelines
- Follow your doctor's instructions strictly regarding dosage and duration.
- Report any unusual side effects or worsening of symptoms immediately.
- Do not stop the medication suddenly without consulting your doctor.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is close to the time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness or drowsiness. If you experience these symptoms, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a healthy diet and lifestyle.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.