Ariflu
Generic Name
Azelastine Hydrochloride 137 mcg Nasal Spray
Manufacturer
Reputable Pharmaceutical Company
Country
Varies
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ariflu 137 mcg nasal spray | ৳ 300.00 | N/A |
Description
Overview of the medicine
Ariflu Nasal Spray contains Azelastine Hydrochloride, an antihistamine, used to relieve seasonal and perennial allergic rhinitis symptoms like runny nose, sneezing, and itchy nose.
Uses & Indications
Dosage
Adults
Adults and adolescents 12 years and older: 2 sprays per nostril twice daily.
Elderly
No specific dose adjustment required for elderly.
Renal_impairment
No specific dose adjustment required for renal impairment.
How to Take
For intranasal use only. Prime the pump before first use or if not used for more than 3 days. Blow nose to clear nostrils. Tilt head forward slightly, insert nozzle into nostril, and spray while sniffing gently. Repeat for the other nostril. Avoid spraying into eyes.
Mechanism of Action
Azelastine is a phthalazinone derivative that exhibits potent H1-receptor antagonist properties and also has mast cell stabilizing and anti-inflammatory effects. It inhibits the release of histamine and other mediators involved in allergic reactions.
Pharmacokinetics
Onset
Within 15-30 minutes.
Excretion
Excreted primarily in feces, with a smaller amount in urine.
Half life
Approximately 20-25 hours for Azelastine, and about 54 hours for the primary metabolite desmethylazelastine.
Absorption
Systemic absorption is low after intranasal administration. Bioavailability is approximately 40%.
Metabolism
Hepatic metabolism by cytochrome P450 (CYP3A4) to active and inactive metabolites, primarily desmethylazelastine.
Side Effects
Contraindications
- •Hypersensitivity to Azelastine or any component of the formulation.
- •Children under 5 years of age.
Drug Interactions
Cimetidine
May increase azelastine plasma levels (though clinical significance is limited due to low systemic absorption).
Alcohol and CNS Depressants
Concurrent use may cause additive CNS depression. Avoid alcohol or use with caution with other CNS depressants.
Storage
Store at room temperature (20°C to 25°C), away from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, and headache. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and potential benefits outweigh risks. Caution is advised during lactation; consult a healthcare professional.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months when unopened, refer to product label.
Availability
Pharmacies
Approval Status
Approved by regulatory bodies
Patent Status
Patent expired, generic available
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Global Brand Names
International brand names for this medicine
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