Arinet
Generic Name
Sertraline
Manufacturer
Beacon Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| arinet 50 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Arinet 50 mg Tablet contains Sertraline, a selective serotonin reuptake inhibitor (SSRI) used to treat major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD). It helps to restore the balance of a certain natural substance (serotonin) in the brain.
Uses & Indications
Dosage
Adults
Initial dose: 25-50 mg once daily. Maintenance dose: 50-200 mg once daily. Adjust dose gradually based on response and tolerability, typically in increments of 25-50 mg at intervals of at least one week.
Elderly
Similar to adult dosage, but use caution and consider starting at a lower dose (e.g., 25 mg daily) and titrate slowly.
Renal_impairment
No dosage adjustment is generally required for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Arinet 50 mg Tablet should be taken orally once daily, with or without food. It is recommended to take it at the same time each day.
Mechanism of Action
Sertraline selectively inhibits the reuptake of serotonin (5-HT) by the presynaptic neuron, thereby increasing the concentration of serotonin in the synaptic cleft. This leads to enhanced serotonergic neurotransmission in the central nervous system.
Pharmacokinetics
Onset
Therapeutic effects may take 2-4 weeks to become apparent.
Excretion
Approximately 40-45% excreted in urine and 40-45% in feces, largely as metabolites.
Half life
Approximately 26 hours (range 22-36 hours) for parent drug; N-desmethylsertraline has a longer half-life (62-104 hours).
Absorption
Well absorbed after oral administration, peak plasma concentrations occur within 4.5-8.4 hours. Food slightly increases absorption.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19, CYP2B6, CYP2D6, CYP3A4, and CYP2C9, to N-desmethylsertraline, which is less active.
Side Effects
Contraindications
- Hypersensitivity to sertraline or any component of the formulation.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
- Concomitant use with pimozide.
Drug Interactions
MAOIs
Risk of serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability, mental status changes).
Pimozide
Increased pimozide levels and cardiotoxicity.
Triptans
Increased risk of serotonin syndrome.
Warfarin
Increased prothrombin time and INR, leading to increased bleeding risk.
NSAIDs/Aspirin
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, vomiting, tachycardia, tremor, agitation, dizziness, and rarely, seizures or coma. Management involves supportive care, maintaining a patent airway, monitoring cardiac and vital signs. Activated charcoal may be useful.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Small amounts of sertraline are excreted in breast milk; caution is advised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to sertraline or any component of the formulation.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
- Concomitant use with pimozide.
Drug Interactions
MAOIs
Risk of serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability, mental status changes).
Pimozide
Increased pimozide levels and cardiotoxicity.
Triptans
Increased risk of serotonin syndrome.
Warfarin
Increased prothrombin time and INR, leading to increased bleeding risk.
NSAIDs/Aspirin
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, vomiting, tachycardia, tremor, agitation, dizziness, and rarely, seizures or coma. Management involves supportive care, maintaining a patent airway, monitoring cardiac and vital signs. Activated charcoal may be useful.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Small amounts of sertraline are excreted in breast milk; caution is advised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Sertraline has undergone numerous clinical trials demonstrating its efficacy and safety for various psychiatric indications, leading to its global approval. Ongoing post-marketing surveillance and new trials continue to explore its uses and effects.
Lab Monitoring
- Baseline liver function tests (LFTs) and periodic monitoring if hepatic impairment is present.
- Monitor serum sodium, especially in elderly patients or those on diuretics, due to risk of hyponatremia.
- Monitor for clinical worsening and suicidality, especially at the beginning of treatment or after dose changes.
Doctor Notes
- Monitor patients for signs of suicidality, especially at initiation and dose changes.
- Educate patients on potential for sexual dysfunction and advise accordingly.
- Gradual tapering is essential to avoid withdrawal symptoms.
Patient Guidelines
- Do not stop taking this medicine abruptly, as it may cause withdrawal symptoms. Consult your doctor for gradual dose reduction.
- It may take several weeks to experience the full benefits. Continue taking it as prescribed.
- Report any unusual mood changes, agitation, or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Arinet may cause dizziness, drowsiness, or visual disturbances. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that sertraline therapy does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Maintain a regular sleep schedule.
- Engage in regular physical activity.
- Practice stress-reduction techniques like meditation or yoga.
- Avoid alcohol and recreational drugs.
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