Aristocort Plus
Generic Name
Triamcinolone Acetonide + Nystatin
Manufacturer
Reputable Pharmaceutical Company
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aristocort plus 1 01 cream | ৳ 40.00 | N/A |
Description
Overview of the medicine
Aristocort Plus Cream is a topical preparation containing a corticosteroid (Triamcinolone Acetonide) and an antifungal (Nystatin). It is used to treat inflamed skin conditions that are complicated by fungal infections, such as candidiasis, often when accompanied by itching, redness, and swelling.
Uses & Indications
Dosage
Adults
Apply a thin film of cream to the affected skin area two to three times daily. Gently rub in. Treatment should not exceed 2 weeks without medical review.
Elderly
No specific dosage adjustments are required for elderly patients. Use with caution, considering potential for thinner skin and increased absorption.
Renal_impairment
No dosage adjustment is necessary for renal impairment as systemic absorption is minimal with topical application.
How to Take
For external use only. Apply a thin layer of cream to the affected skin area and gently massage until absorbed. Wash hands before and after application.
Mechanism of Action
Triamcinolone Acetonide is a synthetic corticosteroid that possesses anti-inflammatory, antipruritic, and vasoconstrictive properties. It reduces the inflammation, redness, and itching associated with various skin conditions. Nystatin is a polyene antifungal antibiotic that works by binding to sterols in the fungal cell membrane, primarily ergosterol. This disrupts the membrane integrity, leading to leakage of essential intracellular components and ultimately cell death.
Pharmacokinetics
Onset
Symptomatic relief from inflammation (itching, redness) typically begins within a few days. Fungal eradication requires consistent application over several days to weeks.
Excretion
Systemically absorbed triamcinolone and its metabolites are excreted mainly by the kidneys. Nystatin is not systemically absorbed, so no significant excretion route applies for topical use.
Half life
Systemic half-life data is not clinically relevant for topical administration due to minimal absorption.
Absorption
Minimal systemic absorption of both triamcinolone acetonide and nystatin occurs when applied topically to intact skin. Absorption can be enhanced by factors such as occlusion, skin integrity, and application to large surface areas.
Metabolism
Any systemically absorbed triamcinolone acetonide is primarily metabolized in the liver. Nystatin is not absorbed through the skin, thus no significant metabolism occurs after topical application.
Side Effects
Contraindications
- •Hypersensitivity to Triamcinolone Acetonide, Nystatin, or any other component of the cream.
- •Primary cutaneous viral infections (e.g., herpes simplex, varicella).
- •Tuberculosis of the skin, acne rosacea, perioral dermatitis.
- •Primary bacterial or fungal infections without significant inflammatory component.
Drug Interactions
None significant due to minimal systemic absorption.
Topical application typically results in minimal systemic absorption, so clinically significant drug interactions are unlikely.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Systemic overdose is unlikely with topical application. However, prolonged or excessive use, especially on large surface areas, occluded skin, or in children, can lead to systemic corticosteroid effects (e.g., Cushing's syndrome, adrenal suppression). Management involves gradual withdrawal of the drug and supportive therapy.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Avoid application to large surface areas or for prolonged periods. For breastfeeding mothers, use with caution. Do not apply to the breast area to prevent ingestion by the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Available in pharmacies and drugstores
Approval Status
Approved by major regulatory bodies
Patent Status
Off-patent
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Global Brand Names
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