Arnac
Generic Name
Diclofenac Sodium
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| arnac 100 mg tablet | ৳ 5.00 | N/A |
Description
Overview of the medicine
Arnac (Diclofenac Sodium) is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain, inflammation, and fever. It is commonly prescribed for conditions such as arthritis, musculoskeletal injuries, and dysmenorrhea.
Uses & Indications
Dosage
Adults
50 mg, 2-3 times daily, preferably with or after food. Maximum recommended dose is 150 mg/day.
Elderly
Generally, the lowest effective dose should be used. Similar to adult dosage, but caution is advised due to increased risk of adverse effects.
Renal_impairment
Dosage adjustment may be necessary in patients with severe renal impairment. Careful monitoring of renal function is recommended.
How to Take
Take orally with a glass of water, preferably with or immediately after food to minimize gastrointestinal upset. Do not crush or chew sustained-release tablets.
Mechanism of Action
Diclofenac Sodium works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Onset of action for pain relief typically within 30-60 minutes.
Excretion
Eliminated predominantly through urine (approximately 60%) and bile/feces (approximately 35%).
Half life
Plasma elimination half-life is approximately 1-2 hours.
Absorption
Rapidly and almost completely absorbed after oral administration. Peak plasma concentrations are reached in 2-3 hours.
Metabolism
Extensively metabolized in the liver, primarily by hydroxylation and subsequent glucuronidation.
Side Effects
Contraindications
- Known hypersensitivity to diclofenac or other NSAIDs (e.g., aspirin-induced asthma)
- Active gastrointestinal bleeding or peptic ulcer
- Severe hepatic or renal impairment
- Severe heart failure
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased lithium levels.
Methotrexate
Increased methotrexate toxicity.
Warfarin/Anticoagulants
Increased risk of bleeding.
Diuretics/Antihypertensives
Reduced efficacy of diuretics and antihypertensives.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy: Contraindicated in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution in the first and second trimesters only if the potential benefit justifies the potential risk to the fetus. Lactation: Diclofenac is excreted into breast milk in small amounts. Use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Available in pharmacies and hospitals across Bangladesh
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Diclofenac has undergone extensive clinical trials establishing its efficacy and safety profile for various pain and inflammatory conditions.
Lab Monitoring
- Renal function (creatinine, BUN)
- Liver function tests (ALT, AST)
- Complete blood count (CBC) with long-term use
Doctor Notes
- Consider patient's cardiovascular and gastrointestinal risk factors before prescribing.
- Use the lowest effective dose for the shortest possible duration.
- Monitor renal function and blood pressure in patients on long-term therapy.
Patient Guidelines
- Take as directed by your doctor, do not exceed the prescribed dose.
- Take with food or milk to reduce stomach upset.
- Inform your doctor if you experience any unusual symptoms, especially severe stomach pain or black/tarry stools.
- Avoid alcohol while taking this medicine.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or visual disturbances. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy lifestyle.
- Avoid smoking and excessive alcohol consumption, as these can increase the risk of gastrointestinal side effects.
- Regular exercise and a balanced diet can support overall joint health.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.