Arokaast
Generic Name
Montelukast Sodium
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| arokast 10 mg tablet | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Arokaast 10 mg Tablet contains Montelukast, a leukotriene receptor antagonist used for the treatment of asthma and allergic rhinitis. It helps to reduce inflammation and relax the airways.
Uses & Indications
Dosage
Adults
10 mg once daily in the evening.
Elderly
No dosage adjustment required.
Renal_impairment
No dosage adjustment required.
How to Take
Take orally, once daily in the evening, with or without food. For asthma, take in the evening. For allergic rhinitis, the timing may be individualized. For exercise-induced bronchoconstriction, take at least 2 hours before exercise.
Mechanism of Action
Montelukast selectively inhibits the cysteinyl leukotriene 1 (CysLT1) receptor. Leukotrienes are potent inflammatory mediators that are released from various cells, including mast cells and eosinophils, and cause bronchoconstriction, mucus secretion, and vascular permeability. By blocking these receptors, Montelukast reduces these inflammatory effects.
Pharmacokinetics
Onset
Within 1 day for asthma symptoms.
Excretion
Primarily excreted in feces via bile (approximately 86%), with less than 0.2% excreted in urine.
Half life
Approximately 2.7 to 5.5 hours.
Absorption
Rapidly and almost completely absorbed after oral administration. Peak plasma concentrations are achieved in approximately 2-4 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (CYP3A4, CYP2C9, CYP2A6).
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the tablet
Drug Interactions
Rifampin
May decrease Montelukast plasma concentrations, possibly by inducing hepatic CYP3A4, 2C8, and 2C9.
Phenobarbital
May decrease Montelukast plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus (Category B). Use with caution during lactation as Montelukast is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the tablet
Drug Interactions
Rifampin
May decrease Montelukast plasma concentrations, possibly by inducing hepatic CYP3A4, 2C8, and 2C9.
Phenobarbital
May decrease Montelukast plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus (Category B). Use with caution during lactation as Montelukast is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated Montelukast's efficacy and safety in asthma and allergic rhinitis across various age groups.
Lab Monitoring
- No specific routine lab monitoring is required.
- Monitor liver function tests periodically in patients with pre-existing liver impairment or if symptoms of liver dysfunction occur.
Doctor Notes
- Emphasize that Montelukast is for long-term control and not for acute relief.
- Counsel patients about potential neuropsychiatric side effects and advise them to seek medical attention if such symptoms occur.
- Review concomitant medications for potential interactions, especially CYP inhibitors/inducers.
Patient Guidelines
- Do not use for acute asthma attacks.
- Continue taking this medicine regularly even if you feel well.
- Report any mood changes or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If a dose is missed, take the next dose at the usual time. Do not double the dose to make up for a missed one.
Driving Precautions
May cause dizziness or drowsiness in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid known asthma triggers and allergens.
- Maintain a healthy lifestyle with regular exercise.
- Do not stop other asthma medications unless advised by a doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.