Aromasin
Generic Name
Exemestane
Manufacturer
Pfizer
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aromasin 25 mg tablet | ৳ 200.00 | ৳ 3,000.00 |
Description
Overview of the medicine
Aromasin (Exemestane) is an oral steroidal aromatase inactivator used in the treatment of breast cancer in postmenopausal women. It works by decreasing the amount of estrogen the body makes.
Uses & Indications
Dosage
Adults
25 mg once daily after a meal.
Elderly
No dosage adjustment required based on age.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment. Data for severe impairment is limited.
How to Take
Aromasin tablets should be taken orally once daily after a meal at approximately the same time each day. Swallowed whole with water.
Mechanism of Action
Exemestane is an irreversible, steroidal aromatase inactivator. It acts as a false substrate for the aromatase enzyme, which converts androgens to estrogens. It is processed by the enzyme, and then covalently binds to the active site, thereby irreversibly inactivating the enzyme. This leads to a significant reduction in circulating estrogen levels in postmenopausal women.
Pharmacokinetics
Onset
Estrogen suppression observed within hours of first dose.
Excretion
Primarily excreted via urine (approximately 40%) and feces (approximately 40%) over 7 days, with negligible amounts of unchanged drug.
Half life
Approximately 24 hours (active metabolite) to 27 hours (parent drug).
Absorption
Rapidly absorbed from the gastrointestinal tract. Peak plasma levels are reached in 1.2 to 2.9 hours. Absorption is increased with fatty meals.
Metabolism
Extensively metabolized by oxidation via the methylene group, followed by glucuronidation. CYP3A4 is the main isoenzyme involved.
Side Effects
Contraindications
- Premenopausal women.
- Women who are pregnant or nursing.
- Patients with a known hypersensitivity to exemestane or any of its excipients.
Drug Interactions
Estrogen-containing products
Should not be co-administered as they may interfere with the pharmacological action of exemestane.
Strong CYP3A4 inducers (e.g., rifampicin, phenytoin, carbamazepine, St. John's wort)
May decrease plasma concentrations of exemestane. Co-administration should be avoided or used with caution.
Storage
Store at room temperature (20°C to 25°C), away from moisture and heat. Keep out of reach of children.
Overdose
There is no specific antidote to exemestane overdose. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Contraindicated in pregnant or lactating women. Exemestane can cause fetal harm when administered to pregnant women. It is not known whether exemestane is excreted in human milk.
Side Effects
Contraindications
- Premenopausal women.
- Women who are pregnant or nursing.
- Patients with a known hypersensitivity to exemestane or any of its excipients.
Drug Interactions
Estrogen-containing products
Should not be co-administered as they may interfere with the pharmacological action of exemestane.
Strong CYP3A4 inducers (e.g., rifampicin, phenytoin, carbamazepine, St. John's wort)
May decrease plasma concentrations of exemestane. Co-administration should be avoided or used with caution.
Storage
Store at room temperature (20°C to 25°C), away from moisture and heat. Keep out of reach of children.
Overdose
There is no specific antidote to exemestane overdose. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Contraindicated in pregnant or lactating women. Exemestane can cause fetal harm when administered to pregnant women. It is not known whether exemestane is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA
Patent Status
Generic versions available
Clinical Trials
Large-scale clinical trials such as the IES (Intergroup Exemestane Study) have demonstrated the efficacy of exemestane in the adjuvant setting for early breast cancer.
Lab Monitoring
- Bone mineral density (BMD) due to risk of bone loss.
- Liver function tests (LFTs) periodically.
- Lipid profiles (cholesterol, triglycerides) periodically.
Doctor Notes
- Monitor bone mineral density regularly in patients on long-term therapy.
- Consider calcium and vitamin D supplementation.
- Advise patients about potential for hot flashes, fatigue, and joint pain.
- Counsel on the importance of adherence, especially given the long-term nature of adjuvant therapy.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Take with food at approximately the same time each day.
- Report any unusual side effects or symptoms to your doctor immediately.
- Do not stop taking this medicine without consulting your doctor.
- Regular bone density scans may be required.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose to catch up.
Driving Precautions
May cause fatigue, dizziness, or drowsiness. Patients should be cautious when driving or operating machinery until they know how Aromasin affects them.
Lifestyle Advice
- Maintain a healthy diet and engage in weight-bearing exercises to support bone health.
- Discuss calcium and vitamin D supplementation with your doctor.
- Avoid alcohol and smoking as they can worsen side effects or compromise overall health.
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