Arth-A
Generic Name
Etodolac
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| arth a 250 mg tablet | ৳ 8.07 | ৳ 80.70 |
Description
Overview of the medicine
Arth-A 250 mg Tablet contains Etodolac, a non-steroidal anti-inflammatory drug (NSAID), used for the relief of pain, inflammation, and stiffness caused by various arthritic conditions.
Uses & Indications
Dosage
Adults
250 mg to 500 mg, two or three times daily, not exceeding 1000 mg/day.
Elderly
Initial dose should be lower, typically 250 mg twice daily, and carefully titrated based on patient response and tolerability.
Renal_impairment
Use with caution; dose reduction may be necessary in severe impairment. Not recommended for severe renal disease.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Etodolac inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins, mediators of pain and inflammation.
Pharmacokinetics
Onset
Pain relief generally within 30-60 minutes.
Excretion
Excreted primarily via the kidneys (75%) and feces (25%) as inactive metabolites.
Half life
Approximately 6-7 hours.
Absorption
Well absorbed orally; peak plasma concentrations achieved in 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily by glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to Etodolac or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding.
Diuretics
Reduced diuretic and antihypertensive effects.
Methotrexate
Increased methotrexate toxicity.
Storage
Store in a cool, dry place below 30°C, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain. Management includes symptomatic and supportive treatment, gastric lavage, and activated charcoal.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus. Use with caution during early pregnancy and lactation only if clearly needed and benefits outweigh risks.
Side Effects
Contraindications
- Hypersensitivity to Etodolac or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding.
Diuretics
Reduced diuretic and antihypertensive effects.
Methotrexate
Increased methotrexate toxicity.
Storage
Store in a cool, dry place below 30°C, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain. Management includes symptomatic and supportive treatment, gastric lavage, and activated charcoal.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus. Use with caution during early pregnancy and lactation only if clearly needed and benefits outweigh risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Etodolac has been extensively studied in clinical trials for its efficacy and safety in various pain and inflammatory conditions. Post-marketing surveillance data also supports its use.
Lab Monitoring
- Complete Blood Count (CBC)
- Renal function tests (Creatinine, BUN)
- Liver function tests (ALT, AST)
- Blood pressure monitoring
Doctor Notes
- Advise patients to report any signs of gastrointestinal bleeding or cardiovascular issues promptly.
- Consider proton pump inhibitor co-therapy for patients at high risk of GI complications.
- Monitor renal function and blood pressure, especially in elderly or those with pre-existing conditions.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Report any unusual bleeding, persistent stomach pain, or severe rash immediately.
- Avoid concomitant use with other NSAIDs.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet.
- Engage in regular, moderate exercise suitable for your condition.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.