Arthrofen
Generic Name
Diclofenac Sodium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| arthrofen 75 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Arthrofen 75 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever.
Uses & Indications
Dosage
Adults
Typically 75-150 mg daily, in divided doses. For 75 mg tablet, usually one tablet once or twice daily, or as directed by the physician.
Elderly
Initiate at the lower end of the dosing range, with careful monitoring.
Renal_impairment
Reduced dosage and close monitoring are recommended in patients with mild to moderate renal impairment. Avoid in severe renal impairment.
How to Take
Take orally, preferably with or after food, to minimize gastrointestinal upset. Do not crush or chew the tablet.
Mechanism of Action
This medicine works by inhibiting cyclooxygenase (COX) enzymes, thereby reducing the synthesis of prostaglandins, which are responsible for pain and inflammation.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Approximately 60% via urine and 35% via bile/feces.
Half life
Plasma half-life is 1-2 hours; synovial fluid half-life is 3-6 hours.
Absorption
Well absorbed orally, though food may delay absorption.
Metabolism
Extensively metabolized in the liver via hydroxylation and glucuronidation (primarily by CYP2C9, CYP2C8, and CYP3A4 enzymes).
Side Effects
Contraindications
- Hypersensitivity to diclofenac or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels, leading to toxicity.
Diuretics
Reduced diuretic and antihypertensive effects.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors / ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is primarily supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C in first and second trimesters, Category D in third trimester. Avoid during lactation as diclofenac is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Available in pharmacies
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have been conducted globally for diclofenac, establishing its efficacy and safety profile for various pain and inflammatory conditions.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN)
- Liver function tests (e.g., ALT, AST)
- Complete blood count (for long-term therapy)
Doctor Notes
- Monitor patients for cardiovascular and gastrointestinal risks, especially with long-term use.
- Consider co-administration of proton pump inhibitors (PPIs) for gastrointestinal protection in high-risk patients.
- Use the lowest effective dose for the shortest possible duration consistent with individual patient treatment goals.
Patient Guidelines
- Take the medicine with food or milk to reduce stomach upset.
- Do not crush, chew, or break the tablet.
- Report any signs of unusual bleeding, dark stools, or severe stomach pain to your doctor immediately.
- Avoid alcohol while taking this medicine.
- Do not take more than the prescribed dose.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness, drowsiness, or visual disturbances in some individuals. Exercise caution when driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Engage in moderate exercise and maintain a healthy diet, as recommended by your doctor.
- Stay hydrated by drinking adequate fluids.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.