Asix
Generic Name
Asixone
Manufacturer
Medimax Pharmaceuticals Ltd. (hypothetical)
Country
Bangladesh
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Description
Overview of the medicine
Asixone is a loop diuretic primarily used to treat edema (fluid retention) associated with congestive heart failure, liver cirrhosis, and kidney disease. It is also used in the management of hypertension.
Uses & Indications
Dosage
Adults
Edema: Initially 20-80 mg orally as a single dose, increased by 20-40 mg every 6-8 hours until desired effect. Maintenance: 20-80 mg daily. Hypertension: Initially 20 mg twice daily, adjusted based on response.
Elderly
Start with lower doses and titrate gradually to effect, monitoring for dehydration and electrolyte imbalance.
Renal_impairment
Dosage adjustment may be necessary. Higher doses may be required in severe renal impairment, but caution is advised due to risk of ototoxicity.
How to Take
Take Asixone orally, with or without food. It is usually taken in the morning to avoid nocturnal diuresis. Follow your doctor's instructions precisely.
Mechanism of Action
Asixone acts on the thick ascending limb of the loop of Henle in the kidney, inhibiting the Na+-K+-2Cl- cotransporter. This prevents the reabsorption of sodium, potassium, and chloride, leading to increased excretion of water, sodium, chloride, and potassium.
Pharmacokinetics
Onset
Oral: 30-60 minutes; Intravenous: 5 minutes.
Excretion
Primarily excreted unchanged in urine via renal tubular secretion.
Half life
0.5-2 hours, prolonged in renal impairment.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability can vary.
Metabolism
Minimally metabolized in the liver.
Side Effects
Contraindications
- Anuria (absence of urine production)
- Known hypersensitivity to Asixone or sulfonamides
- Hepatic coma and pre-coma
- Severe electrolyte depletion (e.g., severe hypokalemia, hyponatremia)
Drug Interactions
Digoxin
Increased risk of digoxin toxicity due to hypokalemia caused by Asixone.
Lithium
Reduced renal clearance of lithium, leading to increased lithium levels and toxicity.
ACE inhibitors/ARBs
Increased risk of severe hypotension and renal impairment, especially with initial doses.
Aminoglycoside antibiotics
Increased risk of ototoxicity.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce diuretic and antihypertensive effects; increased risk of renal toxicity.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture.
Overdose
Symptoms of overdose include dehydration, electrolyte imbalance (hypokalemia, hyponatremia), hypotension, and metabolic alkalosis. Management involves supportive care, correction of fluid and electrolyte imbalances, and treatment of hypotension.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is excreted in breast milk and may suppress lactation; avoid during breastfeeding if possible.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies and hospitals in Bangladesh
Approval Status
Approved by DGDA (hypothetical)
Patent Status
Patent expired, Generic available
WHO Essential Medicine
YesClinical Trials
Clinical trials have established the efficacy and safety of loop diuretics for the treatment of edema and hypertension. Ongoing research may explore new formulations or combination therapies.
Lab Monitoring
- Serum electrolytes (potassium, sodium, chloride) regularly
- Renal function tests (BUN, creatinine)
- Blood pressure monitoring
Doctor Notes
- Monitor patients closely for fluid and electrolyte balance, especially during initiation of therapy and dose adjustments.
- Educate patients on symptoms of hypokalemia and dehydration.
- Consider potassium supplementation if necessary.
Patient Guidelines
- Take Asixone exactly as prescribed by your doctor.
- Do not stop taking this medication without consulting your doctor.
- Report any signs of dehydration or electrolyte imbalance (e.g., muscle cramps, weakness) immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Asixone may cause dizziness or lightheadedness, especially at the start of treatment or when changing dose. Avoid driving or operating heavy machinery until you know how it affects you.
Lifestyle Advice
- Maintain a low-salt diet as advised by your doctor.
- Monitor your fluid intake and output.
- Avoid standing up too quickly to prevent dizziness.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.