Asmafen
Generic Name
Ketotifen
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| asmafen 1 mg tablet | ৳ 2.00 | ৳ 20.00 |
Description
Overview of the medicine
Ketotifen is a mast cell stabilizer with antihistaminic properties, primarily used for long-term prophylactic treatment of bronchial asthma and allergic conditions.
Uses & Indications
Dosage
Adults
1 mg twice daily with food.
Elderly
No specific dose adjustment generally required, but caution with renal impairment.
Renal_impairment
Dose adjustment may be necessary in severe renal impairment.
How to Take
Oral, with food.
Mechanism of Action
Stabilizes mast cells, preventing release of inflammatory mediators (histamine, leukotrienes). Also possesses H1-receptor blocking activity.
Pharmacokinetics
Onset
Several weeks for full antiasthmatic effect.
Excretion
Excreted mainly in urine (about 60-70% as metabolites), some in feces.
Half life
Approximately 12-24 hours.
Absorption
Well absorbed orally, bioavailability around 50%.
Metabolism
Extensively metabolized in the liver, primarily by N-glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to ketotifen or any component
- Concurrent use with oral antidiabetics (risk of reversible decrease in platelet count)
Drug Interactions
Alcohol
May enhance CNS depressant effects.
Antihistamines
May potentiate sedative effects.
CNS Depressants
May enhance sedative effects.
Oral Antidiabetics
Can cause reversible decrease in platelet count.
Storage
Store below 30°C, protect from light and moisture.
Overdose
Symptoms may include drowsiness, confusion, tachycardia, hypotension. Treatment is supportive and symptomatic. Gastric lavage may be considered.
Pregnancy & Lactation
Consult doctor. Use only if potential benefit outweighs risk. Excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to ketotifen or any component
- Concurrent use with oral antidiabetics (risk of reversible decrease in platelet count)
Drug Interactions
Alcohol
May enhance CNS depressant effects.
Antihistamines
May potentiate sedative effects.
CNS Depressants
May enhance sedative effects.
Oral Antidiabetics
Can cause reversible decrease in platelet count.
Storage
Store below 30°C, protect from light and moisture.
Overdose
Symptoms may include drowsiness, confusion, tachycardia, hypotension. Treatment is supportive and symptomatic. Gastric lavage may be considered.
Pregnancy & Lactation
Consult doctor. Use only if potential benefit outweighs risk. Excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Information available in medical literature regarding its efficacy in asthma prophylaxis.
Lab Monitoring
- Platelet count monitoring if co-administered with oral antidiabetics.
Doctor Notes
- Advise patients not to expect immediate relief from acute asthma attacks.
- Monitor for drowsiness, especially during initiation of therapy.
Patient Guidelines
- Do not stop taking abruptly
- May cause drowsiness, avoid driving or operating machinery
- Take with food to minimize GI upset
Missed Dose Advice
Take as soon as remembered unless it's almost time for the next dose. Do not double dose.
Driving Precautions
May cause drowsiness; caution is advised.
Lifestyle Advice
- Avoid known allergens.
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International brand names for this medicine. Click a brand to search for detailed information.
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