Asmaloc
Generic Name
Ketotifen
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| asmaloc 120 mg syrup | ৳ 30.00 | N/A |
Description
Overview of the medicine
Asmaloc (Ketotifen) is an antihistamine and mast cell stabilizer used for the long-term prophylactic treatment of bronchial asthma, allergic bronchitis, and other allergic conditions. It helps prevent allergic reactions by stabilizing mast cells and blocking histamine receptors.
Uses & Indications
Dosage
Adults
Adults and children over 3 years: 5 mL (1 mg) twice daily with meals. May increase to 10 mL (2 mg) twice daily if needed. For optimal prophylactic effect, treatment should be continued for at least 2-3 months.
Elderly
No specific dosage adjustment required for elderly patients, generally follow adult dosage.
Renal_impairment
No specific dosage adjustment recommended for mild to moderate renal impairment. Use with caution in severe impairment, as metabolites are renally excreted.
How to Take
Take orally, preferably with meals to minimize gastrointestinal upset. It is a long-term prophylactic treatment and should not be used for acute asthma attacks.
Mechanism of Action
Ketotifen inhibits the release of inflammatory mediators (e.g., histamine, leukotrienes) from mast cells. It also acts as a non-competitive H1-antihistamine, blocking histamine's effects. Additionally, it may reduce eosinophil recruitment and activation, contributing to its anti-asthmatic effects.
Pharmacokinetics
Onset
Antihistaminic effects within 2-4 hours; prophylactic anti-asthmatic effects may take several weeks (4-10 weeks) to develop fully.
Excretion
Mainly excreted in urine (approximately 60-70% as metabolites) and feces.
Half life
Biphasic elimination: 3-5 hours (initial) and 21 hours (terminal).
Absorption
Well absorbed orally, approximately 60% bioavailability due to first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily via N-demethylation and glucuronidation.
Side Effects
Contraindications
- •Hypersensitivity to Ketotifen or any component of the formulation
- •Concomitant use with oral antidiabetics (can cause reversible thrombocytopenia)
Drug Interactions
Oral Antidiabetics
Concomitant use may increase the risk of reversible thrombocytopenia.
Other antihistamines
Additive sedative effects.
CNS depressants (e.g., alcohol, sedatives, hypnotics)
May potentiate the sedative effects of these drugs.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, confusion, disorientation, nystagmus, convulsions, and respiratory depression. Treatment is supportive and symptomatic; gastric lavage or activated charcoal may be considered. Closely monitor vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Not recommended during breastfeeding as Ketotifen is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, check product label.
Availability
Pharmacies, Hospitals
Approval Status
Approved (General)
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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