Asmatab
Generic Name
Montelukast
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| asmatab 5 mg chewable tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Asmatab 5 mg Chewable Tablet contains Montelukast, a leukotriene receptor antagonist. It is used for the prevention and long-term treatment of asthma and for the relief of symptoms of seasonal and perennial allergic rhinitis.
Uses & Indications
Dosage
Adults
For children 6-14 years: 5 mg once daily in the evening. For adults with specific conditions (e.g., EIB), 10 mg is usually prescribed.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment.
How to Take
Administer orally, once daily in the evening. The tablet should be chewed completely before swallowing. Can be taken with or without food.
Mechanism of Action
Montelukast selectively blocks the CysLT1 receptor, preventing the binding of cysteinyl leukotrienes (LTC4, LTD4, LTE4). These leukotrienes are potent inflammatory mediators released from various cells, including mast cells and eosinophils, and are involved in the pathophysiology of asthma and allergic rhinitis.
Pharmacokinetics
Onset
Clinical benefits in asthma typically seen within one day.
Excretion
Excreted almost exclusively via the bile in feces.
Half life
Plasma half-life ranges from 2.7 to 5.5 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are achieved in approximately 2-4 hours for chewable tablets.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 isoenzymes CYP3A4 and CYP2C9.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation
Drug Interactions
Rifampicin
May decrease montelukast plasma levels by inducing hepatic metabolism.
Phenobarbital
May decrease montelukast plasma levels by inducing hepatic metabolism.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include thirst, somnolence, abdominal pain, psychomotor hyperactivity, and headache. Treatment is symptomatic and supportive. It is not known whether montelukast is dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. There are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Montelukast is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation
Drug Interactions
Rifampicin
May decrease montelukast plasma levels by inducing hepatic metabolism.
Phenobarbital
May decrease montelukast plasma levels by inducing hepatic metabolism.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include thirst, somnolence, abdominal pain, psychomotor hyperactivity, and headache. Treatment is symptomatic and supportive. It is not known whether montelukast is dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. There are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Montelukast is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available, original patent expired
Clinical Trials
Montelukast has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in the treatment of asthma and allergic rhinitis across various age groups. Key trials have shown significant improvement in lung function, reduction in asthma exacerbations, and symptom relief for allergic rhinitis compared to placebo.
Lab Monitoring
- No routine laboratory monitoring is required. Liver function tests may be considered in patients with pre-existing hepatic impairment or if symptoms of liver dysfunction occur. Eosinophil counts if Churg-Strauss syndrome is suspected.
Doctor Notes
- Counsel patients and caregivers on the risk of neuropsychiatric adverse events (agitation, depression, suicidal thoughts) and advise immediate medical consultation if symptoms appear.
- Stress that Montelukast is a prophylactic treatment and not for acute asthma attacks; patients should continue using their rescue inhalers as prescribed.
- Advise patients to take the medication consistently once daily in the evening for optimal therapeutic effect.
Patient Guidelines
- Take Asmatab 5 mg once daily in the evening, even if you feel well.
- Do not stop taking Asmatab without consulting your doctor.
- Report any mood changes, sleep disturbances, or unusual behavior to your doctor immediately.
- Asmatab is not for acute asthma attacks; use a rescue inhaler for sudden breathing problems.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Identify and avoid asthma and allergy triggers.
- Maintain a healthy lifestyle, including regular exercise (if appropriate) and a balanced diet.
- Quit smoking and avoid exposure to secondhand smoke.
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