Atezen
Generic Name
Atezolizumab
Manufacturer
Roche
Country
Switzerland
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| atezen 50 mg tablet | ৳ 0.77 | ৳ 7.70 |
| atezen 100 mg tablet | ৳ 1.37 | ৳ 13.70 |
Description
Overview of the medicine
Atezolizumab is a programmed death-ligand 1 (PD-L1) blocking antibody indicated for the treatment of several types of cancers.
Uses & Indications
Dosage
Adults
1200 mg every 3 weeks or 840 mg every 2 weeks, administered intravenously.
Elderly
Dosage adjustments are not generally required in elderly patients.
Renal_impairment
No dosage adjustment is recommended for patients with mild or moderate renal impairment. Data are limited in patients with severe renal impairment.
How to Take
Administered intravenously by a healthcare professional. Must be diluted prior to administration.
Mechanism of Action
Atezolizumab binds to PD-L1, blocking its interaction with PD-1 and B7.1 receptors. This removes inhibition of T-cells, restoring their anti-tumor activity.
Pharmacokinetics
Onset
Therapeutic effect typically observed after several treatment cycles.
Excretion
Excretion is primarily via catabolic pathways.
Half life
Approximately 27 days.
Absorption
Atezolizumab is administered intravenously, resulting in complete bioavailability.
Metabolism
Atezolizumab is metabolized by proteolytic degradation.
Side Effects
Contraindications
- Hypersensitivity to atezolizumab or any of its excipients
- Active autoimmune disease requiring systemic immunosuppression
Drug Interactions
Immunosuppressants
May increase the risk of immune-mediated adverse reactions.
Systemic Corticosteroids
Concomitant use may decrease the efficacy of atezolizumab.
Storage
Store in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light.
Overdose
There is no specific information on overdose of atezolizumab. Manage patients with close monitoring and symptomatic treatment.
Pregnancy & Lactation
Atezolizumab can cause fetal harm when administered to a pregnant woman. Advise females of reproductive potential to use effective contraception during treatment and for at least 5 months after the last dose. It is not known whether atezolizumab is excreted in human milk; therefore, breastfeeding is not recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Hospitals and specialized oncology pharmacies
Approval Status
FDA Approved
Patent Status
Patented
Clinical Trials
Several clinical trials have demonstrated the efficacy of atezolizumab in various cancers.
Lab Monitoring
- Liver function tests (LFTs)
- Thyroid function tests (TFTs)
- Complete blood count (CBC)
Doctor Notes
- Monitor patients closely for immune-mediated adverse reactions.
- Educate patients about potential side effects and when to seek medical attention.
Patient Guidelines
- Report any new or worsening side effects to your doctor immediately.
- Adhere to the scheduled infusion appointments.
- Use effective contraception if you are a woman of childbearing potential.
Missed Dose Advice
Contact your doctor or healthcare provider immediately for further instructions.
Driving Precautions
Atezolizumab may cause fatigue. Exercise caution while driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet.
- Get adequate rest.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.