Atrizin
Generic Name
Cetirizine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| atrizin 25 mg pediatric drop | ৳ 25.00 | N/A |
Description
Overview of the medicine
Atrizin Pediatric Drop contains Cetirizine, a non-sedating antihistamine, used to relieve symptoms of allergic conditions in children. It helps alleviate runny nose, sneezing, watery eyes, and itching due to hay fever or other upper respiratory allergies, and also symptoms of chronic urticaria.
Uses & Indications
Dosage
Children_2_to_6_years
2.5 mg (0.1 mL) twice daily or 5 mg (0.2 mL) once daily, or as directed by physician.
Children_over_6_years
5 mg (0.2 mL) twice daily or 10 mg (0.4 mL) once daily, or as directed by physician.
Children_6_months_to_2_years
2.5 mg (0.1 mL) once daily. May be increased to a maximum of 2.5 mg (0.1 mL) twice daily if necessary, or as directed by physician.
Renal_hepatic_impairment_children
Dosage adjustment may be necessary in children with renal or hepatic impairment. Consult a physician.
How to Take
Administer orally using the calibrated dropper provided. Can be taken with or without food. Ensure accurate measurement of dose.
Mechanism of Action
Cetirizine is a potent and highly selective H1-receptor antagonist. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Pharmacokinetics
Onset
Within 20-60 minutes.
Excretion
Mainly excreted unchanged in urine (about 60% within 24 hours), and some through feces.
Half life
Approximately 7-11 hours in children (varies with age), 10 hours in adults.
Absorption
Rapidly and extensively absorbed after oral administration. Peak plasma concentrations are reached within 1 hour.
Metabolism
Minimal hepatic metabolism (approximately 10%).
Side Effects
Contraindications
- Hypersensitivity to Cetirizine, hydroxyzine, or any other piperazine derivative.
- Patients with severe renal impairment (creatinine clearance less than 10 mL/min).
Drug Interactions
Ritonavir
Ritonavir may increase plasma levels of cetirizine. Exercise caution.
CNS Depressants
Concurrent use with alcohol or other CNS depressants may cause additive CNS depression (e.g., increased drowsiness).
Storage
Store below 30°C in a dry place, away from direct light and moisture. Do not freeze. Keep bottle tightly closed.
Overdose
Symptoms of overdose may include drowsiness, agitation, restlessness. Management involves symptomatic and supportive treatment. Gastric lavage may be considered if ingestion is recent.
Pregnancy & Lactation
Generally not applicable for pediatric drops. For general guidance: Pregnancy Category B. Consult a physician before use during pregnancy or lactation if applicable for an adult formulation. Cetirizine is excreted into breast milk.
Side Effects
Contraindications
- Hypersensitivity to Cetirizine, hydroxyzine, or any other piperazine derivative.
- Patients with severe renal impairment (creatinine clearance less than 10 mL/min).
Drug Interactions
Ritonavir
Ritonavir may increase plasma levels of cetirizine. Exercise caution.
CNS Depressants
Concurrent use with alcohol or other CNS depressants may cause additive CNS depression (e.g., increased drowsiness).
Storage
Store below 30°C in a dry place, away from direct light and moisture. Do not freeze. Keep bottle tightly closed.
Overdose
Symptoms of overdose may include drowsiness, agitation, restlessness. Management involves symptomatic and supportive treatment. Gastric lavage may be considered if ingestion is recent.
Pregnancy & Lactation
Generally not applicable for pediatric drops. For general guidance: Pregnancy Category B. Consult a physician before use during pregnancy or lactation if applicable for an adult formulation. Cetirizine is excreted into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date, refer to packaging for exact date.
Availability
Pharmacies, Hospitals
Approval Status
Approved (DGDA, Bangladesh - likely)
Patent Status
Patent Expired
Clinical Trials
Cetirizine has undergone extensive clinical trials in both adult and pediatric populations, demonstrating its efficacy and safety for allergic conditions.
Lab Monitoring
- No specific laboratory monitoring is generally required for Cetirizine in pediatric use. Liver and kidney function tests may be considered in patients with pre-existing impairment.
Doctor Notes
- Emphasize accurate dosing for pediatric patients to avoid under- or over-dosing.
- Advise parents on potential for mild sedation and to observe child's response.
Patient Guidelines
- Use the provided dropper for accurate dosing.
- Do not exceed the recommended dose.
- Consult a doctor if symptoms do not improve or worsen.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Not applicable for pediatric patients. For adult caregivers: Cetirizine may cause drowsiness in some individuals. Caution should be exercised when driving or operating machinery.
Lifestyle Advice
- Identify and avoid known allergens.
- Maintain good hygiene to reduce exposure to allergens.
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