Avilam
Generic Name
Pheniramine Maleate
Manufacturer
Various (e.g., Sanofi as Avil)
Country
Global (including Bangladesh)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| avilam 150 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
Pheniramine Maleate is a first-generation antihistamine used to relieve symptoms of allergies such as runny nose, sneezing, itchy eyes/nose/throat, and skin rashes. It can also cause drowsiness.
Uses & Indications
Dosage
Adults
Oral: 25-50 mg every 4-6 hours. Parenteral: 22.75 mg (1 ml) IM/IV, repeated as needed.
Elderly
Start with lower doses due to increased sensitivity to anticholinergic effects and sedation.
Renal_impairment
Use with caution; dose adjustment may be necessary in severe renal impairment.
How to Take
Oral tablets can be taken with or without food. Injections are administered intramuscularly or slowly intravenously.
Mechanism of Action
Pheniramine Maleate acts as a competitive antagonist of histamine H1 receptors. By blocking histamine's action, it reduces the allergic response. It also has anticholinergic effects.
Pharmacokinetics
Onset
Approximately 15-60 minutes (oral)
Excretion
Primarily excreted in the urine as metabolites and unchanged drug.
Half life
10-19 hours
Absorption
Well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Extensively metabolized in the liver.
Side Effects
Contraindications
- •Hypersensitivity to pheniramine or other antihistamines
- •Acute asthma attacks
- •Newborns or premature infants
- •Narrow-angle glaucoma
- •Prostatic hypertrophy with urinary retention
Drug Interactions
Anticholinergics (TCAs, MAOIs)
Increased anticholinergic side effects (e.g., dry mouth, urinary retention).
Monoamine Oxidase Inhibitors (MAOIs)
May prolong and intensify the anticholinergic and CNS depressant effects of antihistamines.
CNS Depressants (alcohol, sedatives, hypnotics)
Increased sedative effect.
Storage
Store below 30°C in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms include severe drowsiness, dizziness, incoordination, dry mouth, fixed dilated pupils, flushing, gastrointestinal symptoms, and in children, CNS excitation (hallucinations, convulsions). Management involves symptomatic and supportive care; gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Avoid during the third trimester. Not recommended during lactation as it may be excreted in breast milk and cause sedation in infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, check specific product packaging.
Availability
Pharmacies, hospitals, clinics
Approval Status
Widely approved globally for decades
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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