Axovit
Generic Name
Thiamine Hydrochloride (Vitamin B1)
Manufacturer
Reputable Pharmaceutical Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| axovit 100 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Axovit 100 mg Tablet is a vitamin B1 supplement used to treat or prevent thiamine deficiency, which can lead to conditions like beriberi and Wernicke-Korsakoff syndrome. It is essential for carbohydrate metabolism and nerve function.
Uses & Indications
Dosage
Adults
For mild deficiency: 10-25 mg daily. For severe deficiency/beriberi: 10-30 mg three times daily. For Wernicke-Korsakoff: 100 mg daily or as directed by physician.
Elderly
Same as adults, but may require lower doses if renal function is impaired.
Renal_impairment
No specific dose adjustment required for mild to moderate impairment. Use with caution in severe impairment.
How to Take
Take orally with water, with or without food.
Mechanism of Action
Thiamine acts as a coenzyme in carbohydrate metabolism, specifically in the decarboxylation of alpha-keto acids like pyruvate and alpha-ketoglutarate. It is crucial for energy production and normal nerve function.
Pharmacokinetics
Onset
Rapid, typically within hours for metabolic effects.
Excretion
Excreted in the urine as metabolites and unchanged thiamine.
Half life
Approximately 9-18 days for its active form, TPP.
Absorption
Readily absorbed from the gastrointestinal tract, primarily in the duodenum.
Metabolism
Metabolized in the liver.
Side Effects
Contraindications
- •Hypersensitivity to thiamine or any component of the formulation.
Drug Interactions
Alcohol
Chronic alcohol consumption can reduce thiamine absorption and increase its excretion.
Neuromuscular blockers
Large doses of thiamine may theoretically enhance the effects of neuromuscular blockers.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Thiamine is a water-soluble vitamin and generally considered non-toxic, even in high doses. No specific antidote. Symptomatic and supportive treatment if adverse effects occur.
Pregnancy & Lactation
Generally considered safe in recommended doses during pregnancy and lactation. Thiamine is an essential vitamin. Consult a doctor for therapeutic doses.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, drugstores
Approval Status
Approved
Patent Status
Expired
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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