Azibact
Generic Name
Azithromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| azibact 500 mg tablet | ৳ 35.00 | ৳ 105.00 |
Description
Overview of the medicine
Azibact 500 mg Tablet contains Azithromycin, a macrolide antibiotic used to treat various bacterial infections of the respiratory tract, skin, ears, eyes, and sexually transmitted diseases.
Uses & Indications
Dosage
Adults
Typical dose: 500 mg once daily for 3 days OR 500 mg on day 1 followed by 250 mg once daily for 4 days. For certain STIs: a single 1g dose.
Elderly
No specific dosage adjustment required unless severe renal or hepatic impairment is present.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Caution advised in severe impairment.
How to Take
Take orally, with or without food. However, food may decrease peak plasma concentrations but not overall absorption. It is often recommended to take it at the same time each day.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby preventing peptide translocation.
Pharmacokinetics
Onset
Clinical effects usually observed within hours to days, depending on the infection.
Excretion
Mainly excreted unchanged in the bile; a small portion is excreted renally.
Half life
Prolonged terminal elimination half-life of 2-4 days (approximately 68 hours), allowing for once-daily dosing.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%. Peak plasma concentrations are reached in 2-3 hours.
Metabolism
Undergoes extensive hepatic metabolism, primarily N-demethylation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Increased anticoagulant effect.
Cyclosporine
Increased cyclosporine levels.
Antacids (containing aluminum or magnesium)
Decreased peak serum concentrations of azithromycin; administer azithromycin at least 2 hours before or after antacids.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves gastric lavage, general supportive measures, and symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but human data is limited. Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Increased anticoagulant effect.
Cyclosporine
Increased cyclosporine levels.
Antacids (containing aluminum or magnesium)
Decreased peak serum concentrations of azithromycin; administer azithromycin at least 2 hours before or after antacids.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves gastric lavage, general supportive measures, and symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but human data is limited. Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved (Generic availability)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Azithromycin's efficacy and safety for various bacterial infections. Ongoing research explores its potential in other areas.
Lab Monitoring
- Liver function tests (especially in patients with pre-existing hepatic impairment or prolonged therapy).
- Renal function tests (in patients with severe renal impairment).
Doctor Notes
- Counsel patients on the importance of completing the full course to prevent resistance.
- Monitor for signs of QT prolongation, especially in patients with pre-existing cardiac conditions or those on other QT-prolonging drugs.
- Advise patients to report any severe gastrointestinal symptoms or signs of allergic reactions.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve, to prevent resistance.
- Report any severe side effects immediately to your doctor.
- Do not share this medication with others.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness or blurred vision in some individuals. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption if it exacerbates gastrointestinal upset or other side effects.
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Global Brand Names
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