Azimex
Generic Name
Azithromycin
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| azimex 200 mg suspension | ৳ 95.00 | N/A |
Description
Overview of the medicine
Azithromycin is a macrolide antibiotic used to treat a wide variety of bacterial infections. It works by stopping the growth of bacteria. This suspension form is particularly suitable for children and adults who have difficulty swallowing tablets.
Uses & Indications
Dosage
Adults
Typically, 500 mg (12.5 ml of 200mg/5ml suspension) once daily for 3 days, or 500 mg on day 1 followed by 250 mg once daily for 4 days.
Elderly
No specific dose adjustment is needed based on age alone.
Children
10 mg/kg once daily for 3 days, or 10 mg/kg on day 1 followed by 5 mg/kg on days 2-5. Maximum single dose 500 mg.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment (creatinine clearance > 10 ml/min).
How to Take
Administer orally, with or without food. For suspension, shake the bottle well before each use. Use the provided measuring device (cup/syringe) for accurate dosing.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby interfering with mRNA translation.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved within 2-3 hours.
Excretion
Mainly excreted unchanged in bile; a small amount is excreted via urine.
Half life
The terminal elimination half-life is prolonged, approximately 2-4 days.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%.
Metabolism
Undergoes hepatic metabolism, primarily N-demethylation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Warfarin
Increased anticoagulant effect. Monitor International Normalized Ratio (INR) regularly.
Nelfinavir
Significant increase in azithromycin serum concentrations. No dose adjustment needed for azithromycin, but monitor for known side effects.
Antacids (containing aluminum or magnesium)
May decrease peak serum concentrations; administer azithromycin at least 1 hour before or 2 hours after antacids.
QT-prolonging drugs (e.g., antiarrhythmics, cisapride, terfenadine)
Increased risk of cardiac arrhythmias. Avoid concomitant use if possible.
Storage
Store dry powder below 30°C, protected from light and moisture. Do not freeze. Keep the reconstituted suspension refrigerated (2-8°C) and discard after the specified period.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, and reversible hearing loss. Management involves gastric lavage and general supportive measures as needed.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Azithromycin is excreted in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Warfarin
Increased anticoagulant effect. Monitor International Normalized Ratio (INR) regularly.
Nelfinavir
Significant increase in azithromycin serum concentrations. No dose adjustment needed for azithromycin, but monitor for known side effects.
Antacids (containing aluminum or magnesium)
May decrease peak serum concentrations; administer azithromycin at least 1 hour before or 2 hours after antacids.
QT-prolonging drugs (e.g., antiarrhythmics, cisapride, terfenadine)
Increased risk of cardiac arrhythmias. Avoid concomitant use if possible.
Storage
Store dry powder below 30°C, protected from light and moisture. Do not freeze. Keep the reconstituted suspension refrigerated (2-8°C) and discard after the specified period.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, and reversible hearing loss. Management involves gastric lavage and general supportive measures as needed.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Azithromycin is excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months for dry powder. Once reconstituted, typically 5-10 days when stored under refrigeration.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of azithromycin for various bacterial infections across different age groups, leading to its widespread approval and use.
Lab Monitoring
- Liver function tests (for prolonged use or in patients with pre-existing hepatic impairment)
- Renal function tests (if necessary, especially in severe impairment)
Doctor Notes
- Emphasize the importance of completing the full course to prevent resistance.
- Counsel parents/caregivers on accurate measurement of liquid doses, especially in children.
- Be mindful of potential QT prolongation, particularly in patients with cardiac conditions or concurrent QT-prolonging medications.
Patient Guidelines
- Complete the entire course of medication as prescribed, even if symptoms improve.
- Shake the suspension bottle well before each use to ensure proper mixing.
- Report any severe or persistent side effects, especially severe diarrhea, abdominal pain, or signs of an allergic reaction.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to make up for a missed one.
Driving Precautions
Azithromycin may cause dizziness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain good hygiene to prevent the spread of infections.
- Ensure adequate hydration during the course of treatment.
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International brand names for this medicine. Click a brand to search for detailed information.
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