Azobrin
Generic Name
Azithromycin 1% Ophthalmic Suspension
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| azobrin 1 suspension | ৳ 500.00 | N/A |
Description
Overview of the medicine
Azobrin 1% Suspension is an ophthalmic antibiotic used to treat bacterial conjunctivitis caused by susceptible microorganisms. It contains Azithromycin, a macrolide antibiotic that inhibits bacterial protein synthesis.
Uses & Indications
Dosage
Adults
Bacterial conjunctivitis: Instill 1 drop into the affected eye(s) twice daily for 2 days, then 1 drop once daily for 5 days. Trachoma: Single dose of 1 drop in each eye.
Elderly
No specific dose adjustment required.
Renal_impairment
No specific dose adjustment required due to minimal systemic absorption.
How to Take
For ophthalmic use only. Shake well before use. Do not touch the dropper tip to any surface to avoid contamination. If using other eye drops, wait at least 5 minutes before applying Azobrin.
Mechanism of Action
Azithromycin binds to the 50S ribosomal subunit of susceptible microorganisms and, thus, inhibits protein synthesis by blocking transpeptidation. It does not affect nucleic acid synthesis.
Pharmacokinetics
Onset
Clinical improvement often seen within 2-3 days.
Excretion
Mainly via bile and feces for systemically absorbed drug. Minimal excretion via urine with ophthalmic use.
Half life
Systemic half-life is long (2-4 days) but local ocular kinetics differ. Data for ophthalmic use is limited for systemic half-life.
Absorption
Minimal systemic absorption after ocular administration. Local concentrations are high.
Metabolism
Primarily hepatic, but systemic metabolism is minimal with ophthalmic use.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, any macrolide antibiotic, or any component of the formulation.
Drug Interactions
Systemic interactions
None significant for ophthalmic use due to minimal systemic absorption.
Storage
Store at controlled room temperature (20°C to 25°C). Do not freeze. Keep out of reach of children.
Overdose
Overdose from ophthalmic administration is unlikely due to small volume and minimal systemic absorption. If accidental oral ingestion occurs, symptomatic and supportive measures should be taken.
Pregnancy & Lactation
Category B. Use during pregnancy only if clearly needed. Excretion into breast milk is minimal with ophthalmic use; generally considered safe.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, any macrolide antibiotic, or any component of the formulation.
Drug Interactions
Systemic interactions
None significant for ophthalmic use due to minimal systemic absorption.
Storage
Store at controlled room temperature (20°C to 25°C). Do not freeze. Keep out of reach of children.
Overdose
Overdose from ophthalmic administration is unlikely due to small volume and minimal systemic absorption. If accidental oral ingestion occurs, symptomatic and supportive measures should be taken.
Pregnancy & Lactation
Category B. Use during pregnancy only if clearly needed. Excretion into breast milk is minimal with ophthalmic use; generally considered safe.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 years unopened. Discard 28 days after opening.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by major regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support its efficacy and safety for bacterial conjunctivitis and trachoma.
Lab Monitoring
- Not typically required for ophthalmic use.
Doctor Notes
- Advise patients on proper instillation technique.
- Emphasize completion of the full course to prevent recurrence and resistance.
- Counsel on potential temporary blurred vision.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Remove contact lenses before application and wait 15 minutes before reinserting.
- Avoid touching the tip of the dropper to prevent contamination.
Missed Dose Advice
If a dose is missed, apply it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Driving Precautions
May cause temporary blurred vision. Avoid driving or operating machinery until vision is clear.
Lifestyle Advice
- Maintain good hand hygiene.
- Avoid rubbing eyes.
- Do not share eye drops with others.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.