B-50 Forte
Generic Name
Vitamin B-Complex (High Potency)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| b 50 forte 50 mg injection | ৳ 10.03 | N/A |
Description
Overview of the medicine
B-50 Forte 50 mg Injection is a high potency vitamin B-complex formulation used for the prevention and treatment of vitamin B deficiencies, especially in conditions requiring increased vitamin B intake or where oral supplementation is not feasible.
Uses & Indications
Dosage
Adults
Typically 1-2 mL intramuscularly or intravenously, 1-3 times a week, or as directed by physician.
Elderly
No specific dosage adjustment usually required, use with caution in those with renal impairment.
Renal_impairment
Use with caution; dosages may need adjustment in severe renal impairment, though B vitamins are generally safe.
How to Take
Administer intramuscularly or slowly intravenously. For intravenous use, it may be diluted in normal saline or dextrose solution.
Mechanism of Action
B vitamins act as coenzymes in various metabolic pathways, essential for carbohydrate, fat, and protein metabolism, nervous system function, and red blood cell formation.
Pharmacokinetics
Onset
Rapid onset of action due to parenteral administration.
Excretion
Primarily renal excretion of unmetabolized vitamins and their metabolites.
Half life
Varies for each B vitamin; generally short, excreted within hours.
Absorption
Water-soluble vitamins are readily absorbed from the injection site into the systemic circulation.
Metabolism
Metabolized in the liver; some B vitamins are converted to active coenzyme forms.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation
- Leber's disease (due to Cyanocobalamin)
Drug Interactions
Levodopa
Pyridoxine (Vitamin B6) can reduce the efficacy of Levodopa (without carbidopa) in Parkinson's disease.
Phenobarbital, Phenytoin
Pyridoxine may decrease serum levels of these anticonvulsants.
Folic Acid antagonists (e.g., Methotrexate)
May interfere with some B vitamin metabolism.
Storage
Store below 25°C, protect from light. Do not freeze.
Overdose
Due to water-soluble nature, overdose is rare and generally well-tolerated. High doses of Pyridoxine can cause peripheral neuropathy. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy and lactation for increased nutritional needs, but always consult a physician.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation
- Leber's disease (due to Cyanocobalamin)
Drug Interactions
Levodopa
Pyridoxine (Vitamin B6) can reduce the efficacy of Levodopa (without carbidopa) in Parkinson's disease.
Phenobarbital, Phenytoin
Pyridoxine may decrease serum levels of these anticonvulsants.
Folic Acid antagonists (e.g., Methotrexate)
May interfere with some B vitamin metabolism.
Storage
Store below 25°C, protect from light. Do not freeze.
Overdose
Due to water-soluble nature, overdose is rare and generally well-tolerated. High doses of Pyridoxine can cause peripheral neuropathy. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy and lactation for increased nutritional needs, but always consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored correctly.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
Clinical Trials
As a well-established vitamin formulation, new clinical trials are rare for general indications. Studies focus on specific deficiency populations or novel delivery methods.
Lab Monitoring
- Monitor B vitamin levels if deficiency is severe or unresponsive to treatment.
- Monitor liver and kidney function in patients with pre-existing conditions.
Doctor Notes
- Emphasize proper injection technique to avoid pain and nerve damage.
- Assess for underlying causes of vitamin B deficiency.
- Educate patients on diet and lifestyle modifications to prevent recurrence.
Patient Guidelines
- Follow the prescribed dosage and administration instructions carefully.
- Report any unusual side effects to your doctor.
- Do not stop treatment abruptly without consulting your doctor.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Generally no specific precautions. If dizziness or lightheadedness occurs, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet rich in B vitamins.
- Limit alcohol intake, as it can deplete B vitamin stores.
- Manage underlying conditions contributing to deficiency.
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