Baclax
Generic Name
Baclofen
Manufacturer
PharmaCorp Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| baclax 10 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Baclax 10 mg Tablet contains Baclofen, a muscle relaxant used to treat muscle spasms, stiffness, and pain caused by multiple sclerosis, spinal cord injuries, or other neurological conditions. It works by calming the central nervous system.
Uses & Indications
Dosage
Adults
Initially 5 mg three times daily, gradually increasing by 5 mg increments every 3 days to a maximum of 20 mg three times daily.
Elderly
Lower starting dose and slower titration recommended due to increased sensitivity and potential for adverse effects.
Renal_impairment
Dose reduction is necessary. Start with 5 mg daily and titrate carefully.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Do not discontinue abruptly.
Mechanism of Action
Baclofen is a gamma-aminobutyric acid (GABA) mimetic that acts as an agonist at GABA-B receptors. This action reduces the release of excitatory neurotransmitters, leading to muscle relaxation and reduced spasticity.
Pharmacokinetics
Onset
Muscle relaxation effect typically begins within a few hours.
Excretion
Primarily excreted unchanged by the kidneys (70-80%).
Half life
Approximately 3-4 hours.
Absorption
Rapidly and extensively absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 2-3 hours.
Metabolism
Partially metabolized in the liver (less than 15%).
Side Effects
Contraindications
- Hypersensitivity to Baclofen or any component of the formulation.
- Peptic ulcer disease (relative).
- Epilepsy not adequately controlled by therapy.
Drug Interactions
Lithium
Increased risk of toxicity.
Antihypertensives
May cause additive hypotensive effects.
Tricyclic Antidepressants
May potentiate Baclofen's effects.
CNS Depressants (e.g., alcohol, opioids, benzodiazepines)
Increased sedative effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, dizziness, confusion, respiratory depression, seizures, and coma. Treatment is supportive, including gastric lavage, activated charcoal, and respiratory support if needed.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Baclofen is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Baclofen has been extensively studied in clinical trials for spasticity management across various neurological conditions, demonstrating efficacy and an established safety profile.
Lab Monitoring
- Renal function (especially in patients with impairment)
- Liver function tests (periodically)
Doctor Notes
- Counsel patients on the importance of gradual dose reduction.
- Monitor for CNS depression and adjust dose accordingly.
- Assess renal function regularly.
Patient Guidelines
- Do not stop taking Baclofen abruptly, as it can cause withdrawal symptoms.
- Avoid alcohol and other CNS depressants.
- Be aware of drowsiness or dizziness, especially at the start of treatment.
- Take with food or milk.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how you react to the medication.
Lifestyle Advice
- Avoid tasks requiring mental alertness until you know how the medicine affects you.
- Regular exercise and physical therapy can complement drug therapy.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.