Bacofen
Generic Name
Baclofen
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bacofen 10 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Baclofen 10 mg Tablet is a muscle relaxant used to treat muscle spasms, stiffness, and pain caused by certain conditions like multiple sclerosis, spinal cord injury, or other neurological disorders. It helps to improve muscle movement and relieve discomfort.
Uses & Indications
Dosage
Adults
Initial dose is usually 5 mg three times daily for 3 days, then gradually increased by 5 mg every 3 days until optimal response (usually 10-20 mg three times daily). Maximum dose: 80 mg/day.
Elderly
Start with a lower dose (e.g., 5 mg once daily) and increase gradually under close supervision due to increased sensitivity and potential for adverse effects.
Renal_impairment
Dosage should be reduced significantly (e.g., 5 mg once daily). Close monitoring is essential.
How to Take
Bacofen 10 mg Tablet should be taken orally with water, with or without food. It is important to take doses at evenly spaced intervals throughout the day.
Mechanism of Action
Baclofen acts as a gamma-aminobutyric acid (GABA) analogue that selectively binds to GABA-B receptors, primarily at the spinal cord level. This binding leads to hyperpolarization of neurons and reduced release of excitatory neurotransmitters, resulting in decreased spasticity and muscle tone.
Pharmacokinetics
Onset
Onset of action typically occurs within 0.5-1 hour after oral administration.
Excretion
Primarily excreted unchanged by the kidneys (70-80% within 72 hours). A small amount is excreted in feces.
Half life
Plasma elimination half-life is approximately 2.5-4 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 2-3 hours.
Metabolism
Minimally metabolized; about 15% is metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Baclofen or any component of the formulation
- Acute porphyria
Drug Interactions
Antihypertensives
Additive hypotensive effects; monitor blood pressure.
Levodopa/Carbidopa
May lead to increased dyskinesia and confusion.
Tricyclic Antidepressants (TCAs)
May potentiate the effects of baclofen, leading to increased muscle weakness and sedation.
CNS Depressants (e.g., alcohol, benzodiazepines, opioids)
Increased CNS depression, drowsiness, and respiratory depression.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, dizziness, severe muscle weakness, vomiting, respiratory depression, seizures, and coma. Treatment involves supportive care, maintaining airway, and monitoring vital signs. Gastric lavage may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Baclofen is excreted in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to Baclofen or any component of the formulation
- Acute porphyria
Drug Interactions
Antihypertensives
Additive hypotensive effects; monitor blood pressure.
Levodopa/Carbidopa
May lead to increased dyskinesia and confusion.
Tricyclic Antidepressants (TCAs)
May potentiate the effects of baclofen, leading to increased muscle weakness and sedation.
CNS Depressants (e.g., alcohol, benzodiazepines, opioids)
Increased CNS depression, drowsiness, and respiratory depression.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, dizziness, severe muscle weakness, vomiting, respiratory depression, seizures, and coma. Treatment involves supportive care, maintaining airway, and monitoring vital signs. Gastric lavage may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Baclofen is excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific to lot.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
DGDA approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Baclofen's efficacy and safety have been established through numerous clinical trials demonstrating its effectiveness in reducing spasticity associated with various neurological conditions.
Lab Monitoring
- Renal function (especially in patients with renal impairment)
- Liver function tests (periodically during prolonged therapy)
Doctor Notes
- Emphasize gradual dose titration to minimize side effects and optimize therapeutic response.
- Strictly advise patients against abrupt discontinuation due to severe withdrawal risks.
- Monitor for signs of CNS depression, especially when co-administered with other depressants.
- Adjust dose carefully in elderly and renally impaired patients.
Patient Guidelines
- Do not stop taking Baclofen abruptly without consulting your doctor.
- Avoid alcohol and other CNS depressants while on this medication.
- Report any unusual side effects or worsening of symptoms to your doctor.
- Be cautious when driving or operating machinery until you know how this medication affects you.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Baclofen may cause drowsiness, dizziness, and impaired coordination. Patients should be advised not to drive or operate hazardous machinery until they are certain that the medication does not adversely affect their ability to perform such activities.
Lifestyle Advice
- Avoid activities requiring mental alertness, such as driving or operating heavy machinery, especially at the start of treatment or after dose adjustments.
- Maintain regular communication with your healthcare provider regarding your symptoms and any concerns.
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Global Brand Names
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