Baloxa
Generic Name
Baloxavir Marboxil
Manufacturer
Shionogi Co., Ltd.
Country
Japan
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| baloxa 20 mg tablet | ৳ 300.00 | N/A |
Description
Overview of the medicine
Baloxa 20 mg Tablet contains Baloxavir Marboxil, an antiviral medication used for the treatment of acute uncomplicated influenza (flu) in patients 12 years of age and older. It targets the PA endonuclease, an enzyme essential for viral replication.
Uses & Indications
Dosage
Adults
Patients weighing 40 kg to <80 kg: 40 mg single oral dose. Patients weighing <40 kg: 20 mg single oral dose. For this 20mg tablet, it's typically for those <40 kg.
Elderly
No specific dose adjustment required based on age.
Renal_impairment
No dose adjustment recommended for mild or moderate renal impairment. Data for severe renal impairment is limited.
How to Take
Take orally as a single dose, with or without food. Administer within 48 hours of symptom onset.
Mechanism of Action
Baloxavir marboxil is a prodrug that is converted to baloxavir, which inhibits the cap-dependent endonuclease activity of the influenza virus polymerase acidic (PA) protein. This action prevents viral gene transcription, thereby inhibiting influenza virus replication.
Pharmacokinetics
Onset
Symptom improvement within 24-48 hours.
Excretion
Primarily excreted via feces (80%), with a smaller portion via urine (15%).
Half life
Approximately 79.3 hours for baloxavir.
Absorption
Rapidly absorbed and converted to baloxavir. Peak plasma concentrations are reached approximately 4 hours post-dose.
Metabolism
Primarily metabolized by UGT1A3 and to a lesser extent by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to baloxavir marboxil or any component of the formulation.
Drug Interactions
Dairy products or calcium-fortified beverages
May reduce baloxavir absorption. Avoid co-administration.
Polyvalent cation-containing laxatives, antacids, or oral supplements
May chelate baloxavir and reduce absorption. Avoid co-administration.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Symptomatic and supportive treatment should be initiated as appropriate.
Pregnancy & Lactation
Limited data on use in pregnant women; use only if potential benefit justifies potential risk to fetus. Excretion in human milk unknown; caution advised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to baloxavir marboxil or any component of the formulation.
Drug Interactions
Dairy products or calcium-fortified beverages
May reduce baloxavir absorption. Avoid co-administration.
Polyvalent cation-containing laxatives, antacids, or oral supplements
May chelate baloxavir and reduce absorption. Avoid co-administration.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Symptomatic and supportive treatment should be initiated as appropriate.
Pregnancy & Lactation
Limited data on use in pregnant women; use only if potential benefit justifies potential risk to fetus. Excretion in human milk unknown; caution advised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Patented
Clinical Trials
Extensive clinical trials (e.g., CAPSTONE-1, CAPSTONE-2) demonstrated efficacy and safety in influenza patients.
Lab Monitoring
- No routine lab monitoring is generally required. Monitor for clinical improvement of influenza symptoms.
Doctor Notes
- Emphasize single-dose administration and timely initiation (within 48 hours of symptom onset).
- Counsel patients on potential interactions with dairy products and polyvalent cation-containing products.
Patient Guidelines
- Take the entire single dose as prescribed.
- Inform your doctor about all other medications you are taking, including supplements.
- Avoid dairy products, calcium-fortified drinks, and certain antacids or laxatives when taking Baloxa.
Missed Dose Advice
As Baloxa is a single-dose treatment, a missed dose is not applicable. Ensure the single dose is taken as prescribed.
Driving Precautions
Baloxa is not expected to affect the ability to drive or use machines. However, if you experience dizziness or other symptoms, avoid driving.
Lifestyle Advice
- Rest and stay hydrated during influenza infection.
- Practice good hand hygiene to prevent spread of the virus.
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