Barcavir
Generic Name
Barcavir
Manufacturer
PharmaCorp Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| barcavir 1 mg tablet | ৳ 90.00 | ৳ 900.00 |
Description
Overview of the medicine
Barcavir 1 mg Tablet is an antiviral medication used in the treatment of chronic Hepatitis B virus (HBV) infection. It works by inhibiting viral replication, thereby reducing liver damage.
Uses & Indications
Dosage
Adults
The recommended dose for adults with chronic HBV infection is 1 mg once daily, taken orally with or without food.
Elderly
No specific dose adjustment is required for elderly patients based on age alone. However, renal function should be monitored, and dose adjusted if necessary.
Renal_impairment
Dose adjustment is required for patients with creatinine clearance <50 mL/min, including hemodialysis patients. Consult specific guidelines for dosage adjustments.
How to Take
Take the tablet whole with a glass of water. Do not crush, break, or chew the tablet. It can be taken with or without food.
Mechanism of Action
Barcavir is a nucleoside analog that inhibits the Hepatitis B virus reverse transcriptase enzyme. It gets incorporated into viral DNA, leading to chain termination and thus preventing viral DNA synthesis and replication.
Pharmacokinetics
Onset
Viral load reduction typically begins within 1-2 weeks of initiation of therapy.
Excretion
Primarily excreted unchanged in the urine, with renal excretion accounting for approximately 70% of the administered dose.
Half life
Elimination half-life is approximately 24-30 hours, allowing for once-daily dosing.
Absorption
Rapidly absorbed after oral administration, with an oral bioavailability of approximately 80%. Peak plasma concentrations are reached within 0.5-1.5 hours.
Metabolism
Minimally metabolized by the liver. It is not a substrate, inhibitor, or inducer of cytochrome P450 enzymes.
Side Effects
Contraindications
- •Hypersensitivity to Barcavir or any component of the formulation.
- •Severe hepatic impairment (Child-Pugh Class C) without proper evaluation.
Drug Interactions
Other Antivirals
Caution is advised when co-administering with other antiviral drugs, particularly those with similar mechanisms or potential for overlapping toxicities.
Nephrotoxic Agents
Coadministration with nephrotoxic agents (e.g., aminoglycosides, NSAIDs) may increase the risk of renal dysfunction. Increased monitoring of renal function is recommended.
Storage
Store below 25°C in a dry and cool place. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited experience with Barcavir overdose. In case of an overdose, symptomatic and supportive treatment should be initiated. Hemodialysis can remove approximately 13% of the Barcavir dose over a 4-hour period.
Pregnancy & Lactation
Pregnancy Category C. Barcavir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Barcavir is excreted in human milk; however, other nucleoside analogs are. Therefore, caution should be exercised when Barcavir is administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
30 months from the date of manufacture
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Patented
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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