Take the tablet orally once daily in the morning, with or without food. Swallow whole with some liquid, do not chew or crush.

Bisoprolol selectively blocks beta-1 adrenergic receptors in the heart, leading to a decrease in heart rate, myocardial contractility, and cardiac output, thereby reducing blood pressure and myocardial oxygen demand.

• •Acute heart failure or decompensated heart failure requiring intravenous inotropic therapy
• •Cardiogenic shock
• •Second or third degree AV block (without a pacemaker)
• •Sick sinus syndrome
• •Sinoatrial block
• •Severe bradycardia (heart rate < 60 bpm before treatment)
• •Severe hypotension (systolic blood pressure < 100 mmHg)
• •Severe bronchial asthma or severe chronic obstructive pulmonary disease (COPD)
• •Severe forms of peripheral arterial occlusive disease or Raynaud's syndrome
• •Untreated phaeochromocytoma
• •Metabolic acidosis

Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Symptoms of overdose include bradycardia, hypotension, bronchospasm, acute cardiac insufficiency, and hypoglycemia. Management involves symptomatic and supportive treatment; administer atropine for bradycardia, glucagon for hypoglycemia, and beta-agonists for bronchospasm.

Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Bisoprolol is excreted in breast milk; caution is advised when administered to a nursing mother.