Belocef
Generic Name
belocef-125-mg-pediatric-drop
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| belocef 125 mg pediatric drop | ৳ 50.00 | N/A |
Description
Overview of the medicine
Belocef 125 mg Pediatric Drop is an antibiotic medication containing Cefixime, a third-generation cephalosporin, used to treat a wide range of bacterial infections in children.
Uses & Indications
Dosage
Adults
Not applicable for pediatric drops. Adult formulations (tablets/capsules) are available for adult use.
Elderly
Not applicable for pediatric drops. Adult formulations (tablets/capsules) are available for elderly use.
Renal_impairment
For children with creatinine clearance < 20 mL/min, the dosage should be reduced. Consult a physician for specific adjustments.
How to Take
Belocef 125 mg Pediatric Drop is for oral administration only. Reconstitute the dry powder with boiled and cooled water as per instructions on the label. Shake the bottle well before each use. It can be taken with or without food.
Mechanism of Action
Cefixime works by inhibiting the synthesis of the bacterial cell wall, which is essential for the bacteria's survival. This leads to the destruction of the bacterial cells.
Pharmacokinetics
Onset
Peak plasma concentrations are usually achieved within 2-6 hours after oral administration.
Excretion
Cefixime is primarily excreted by the kidneys, with approximately 50% of the absorbed dose excreted unchanged in the urine. Biliary excretion also occurs.
Half life
The average plasma half-life of Cefixime is 3-4 hours, which may be prolonged in patients with renal impairment.
Absorption
Approximately 40-50% of an oral dose of Cefixime is absorbed from the gastrointestinal tract. Food may delay absorption but does not significantly affect the extent of absorption.
Metabolism
Cefixime is not extensively metabolized in the body. Some metabolites may be formed, but most of the drug is excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin (due to potential cross-reactivity).
Drug Interactions
Nifedipine
May increase Cefixime absorption and peak plasma levels.
Carbamazepine
Concomitant administration may increase Carbamazepine levels; monitor Carbamazepine concentrations.
Oral Anticoagulants (e.g., Warfarin)
May increase prothrombin time and INR; monitor coagulation parameters closely.
Storage
Store the dry powder below 30°C in a cool, dry place, away from direct sunlight and moisture. Store the reconstituted suspension at room temperature (15-30°C) for up to 7 days, or refrigerated (2-8°C) for up to 14 days. Do not freeze.
Overdose
In case of overdose, gastric lavage may be considered. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment is primarily symptomatic and supportive.
Pregnancy & Lactation
Cefixime is Pregnancy Category B. It should be used during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unreconstituted dry powder: Varies by manufacturer, typically 24-36 months. Reconstituted suspension: Stable for up to 7-14 days when stored properly.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in treating various bacterial infections in pediatric populations. Studies have confirmed its effectiveness in conditions like otitis media, pharyngitis, and urinary tract infections.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with pre-existing renal impairment).
- Complete blood count (rarely needed for routine use, but may be considered for prolonged or high-dose therapy).
Doctor Notes
- Always inquire about the patient's allergy history, particularly to penicillins and cephalosporins, before prescribing Cefixime.
- Emphasize to parents the critical importance of completing the entire course of antibiotics, even if symptoms improve, to prevent treatment failure and resistance.
- Advise parents on proper reconstitution and administration techniques, including the use of calibrated measuring devices.
- Monitor for signs of superinfection, especially C. difficile-associated diarrhea, with prolonged use.
Patient Guidelines
- Administer the full prescribed course of medication, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
- Shake the reconstituted suspension well before each use to ensure even distribution of the medication.
- Use the provided measuring spoon or dropper for accurate dosing. Do not use household spoons.
- Store the reconstituted suspension as directed and discard any unused portion after the specified period.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Belocef is generally not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness occur, patients should exercise caution.
Lifestyle Advice
- Ensure adequate hydration during treatment.
- Encourage good hygiene practices to prevent the spread of infection.
- Avoid giving other antibiotics without consulting a doctor.
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