Bendil
Generic Name
Betamethasone Valerate 0.1% Cream
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bendil 2 01 cream | ৳ 22.00 | N/A |
Description
Overview of the medicine
Bendil-2-01-Cream contains Betamethasone Valerate, a potent corticosteroid, used to treat various inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin area once or twice daily, as directed by a physician. Rub in gently.
Elderly
No specific dosage adjustments required, use with caution.
Renal_impairment
No specific dosage adjustments required due to minimal systemic absorption.
How to Take
For external use only. Apply a thin layer to the affected skin area and rub in gently. Do not apply to the face, groin, or axillae unless directed by a physician. Avoid contact with eyes.
Mechanism of Action
Betamethasone valerate exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties. It induces phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid.
Pharmacokinetics
Onset
Within hours to days of application.
Excretion
Excreted by the kidneys, and to a lesser extent, in the bile.
Half life
Not well-defined for topical application; systemic half-life of betamethasone is approximately 5 hours.
Absorption
Systemic absorption of topical corticosteroids varies. It can be increased by occlusive dressings, prolonged use, and application to large surface areas or damaged skin. Significant systemic absorption is minimal with proper use.
Metabolism
Metabolized primarily in the liver, similar to systemically administered corticosteroids.
Side Effects
Contraindications
- Hypersensitivity to betamethasone valerate or any component of the cream
- Untreated fungal, bacterial, or viral skin infections (e.g., herpes simplex, varicella)
- Rosacea, acne vulgaris
- Perioral dermatitis
- Pruritus without inflammation
Drug Interactions
CYP3A4 Inhibitors
Coadministration with CYP3A4 inhibitors (e.g., ritonavir, itraconazole) may increase systemic exposure, but this is less likely with topical application.
Systemic Corticosteroids
Increased systemic absorption and potential for Cushing's syndrome with concurrent use of other systemic corticosteroids.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely with topical application. Prolonged and excessive use may lead to systemic effects such as Cushing's syndrome, hyperglycemia, and glucosuria. Management involves gradual withdrawal of the drug and symptomatic treatment.
Pregnancy & Lactation
Use during pregnancy or lactation should only be considered if the potential benefit outweighs the potential risk to the fetus or infant. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to betamethasone valerate or any component of the cream
- Untreated fungal, bacterial, or viral skin infections (e.g., herpes simplex, varicella)
- Rosacea, acne vulgaris
- Perioral dermatitis
- Pruritus without inflammation
Drug Interactions
CYP3A4 Inhibitors
Coadministration with CYP3A4 inhibitors (e.g., ritonavir, itraconazole) may increase systemic exposure, but this is less likely with topical application.
Systemic Corticosteroids
Increased systemic absorption and potential for Cushing's syndrome with concurrent use of other systemic corticosteroids.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely with topical application. Prolonged and excessive use may lead to systemic effects such as Cushing's syndrome, hyperglycemia, and glucosuria. Management involves gradual withdrawal of the drug and symptomatic treatment.
Pregnancy & Lactation
Use during pregnancy or lactation should only be considered if the potential benefit outweighs the potential risk to the fetus or infant. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
Clinical Trials
Clinical trials have demonstrated the efficacy of Betamethasone Valerate 0.1% cream in reducing inflammatory symptoms and improving skin lesions in patients with various corticosteroid-responsive dermatoses.
Lab Monitoring
- Routine lab monitoring is generally not required for topical corticosteroid use.
- In cases of extensive, prolonged use, monitoring for systemic effects (e.g., blood glucose levels) may be considered.
Doctor Notes
- Advise patients to use the minimal effective amount for the shortest duration necessary.
- Warn against prolonged use on the face, groin, or axillae.
- Monitor for signs of skin atrophy, infection, or systemic absorption.
Patient Guidelines
- Use only as directed by your doctor.
- Do not use for longer than prescribed.
- Do not cover the treated area with bandages or other occlusive dressings unless advised by your doctor.
- Wash hands before and after application.
- Avoid applying to the eyes, mouth, or internal body areas.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Bendil-2-01-Cream has no known effect on the ability to drive or operate machinery.
Lifestyle Advice
- Keep the affected skin area clean and moisturized.
- Avoid irritants and allergens that may worsen the skin condition.
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Global Brand Names
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