Benkill
Generic Name
Benicillin
Manufacturer
Pharmaco Industries Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| benkill 500 mg tablet | ৳ 45.00 | ৳ 315.00 |
Description
Overview of the medicine
Benkill 500 mg Tablet is a broad-spectrum antibiotic belonging to the penicillin group. It is used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
250-500 mg every 8 hours or 500-875 mg every 12 hours, depending on infection severity.
Elderly
Same as adults, but dose adjustment may be needed for renal impairment.
Renal_impairment
Dose reduction necessary; e.g., CrCl 10-30 mL/min: 250-500 mg every 12 hours. CrCl < 10 mL/min: 250-500 mg every 24 hours.
How to Take
Can be taken with or without food. To minimize GI upset, take with food.
Mechanism of Action
Benicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Within 30-60 minutes
Excretion
Primarily renal (glomerular filtration and tubular secretion)
Half life
Approximately 1-1.5 hours
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability approx 70-90%.
Metabolism
Limited hepatic metabolism; mainly excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to benicillin or other beta-lactam antibiotics (e.g., penicillins, cephalosporins)
- Infectious mononucleosis (increased risk of rash)
Drug Interactions
Warfarin
May potentiate anticoagulant effects, monitor INR.
Methotrexate
Increased methotrexate toxicity due to reduced renal excretion.
Oral Contraceptives
May decrease efficacy; use additional contraceptive method.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, and convulsions in severe cases. Treatment is symptomatic and supportive; hemodialysis may be used to remove the drug.
Pregnancy & Lactation
Generally considered safe during pregnancy (Category B). Excreted in breast milk in small amounts; generally considered safe for nursing infants but monitor for diarrhea or rash.
Side Effects
Contraindications
- Hypersensitivity to benicillin or other beta-lactam antibiotics (e.g., penicillins, cephalosporins)
- Infectious mononucleosis (increased risk of rash)
Drug Interactions
Warfarin
May potentiate anticoagulant effects, monitor INR.
Methotrexate
Increased methotrexate toxicity due to reduced renal excretion.
Oral Contraceptives
May decrease efficacy; use additional contraceptive method.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, and convulsions in severe cases. Treatment is symptomatic and supportive; hemodialysis may be used to remove the drug.
Pregnancy & Lactation
Generally considered safe during pregnancy (Category B). Excreted in breast milk in small amounts; generally considered safe for nursing infants but monitor for diarrhea or rash.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Benicillin has undergone clinical trials demonstrating its efficacy and safety against various bacterial infections, consistent with other broad-spectrum penicillins.
Lab Monitoring
- Renal function (especially in elderly or impaired patients)
- Liver function tests (periodically during prolonged therapy)
Doctor Notes
- Advise patients to report any signs of allergic reaction immediately.
- Emphasize completion of the full course to minimize resistance.
- Consider renal function in elderly and impaired patients for dose adjustment.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if you feel better.
- Do not share this medicine with others.
- Report any severe allergic reactions immediately.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double dose.
Driving Precautions
Generally, Benkill does not impair the ability to drive or operate machinery. However, if you experience dizziness, avoid such activities.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol consumption during treatment.
- Take probiotics to help manage gut flora disruption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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