Benlor
Generic Name
Bromazepam
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| benlor 5 mg tablet | ৳ 3.50 | ৳ 35.00 |
Description
Overview of the medicine
Bromazepam is a benzodiazepine derivative with anxiolytic, sedative, and muscle relaxant properties, primarily used for the short-term management of anxiety and panic disorders.
Uses & Indications
Dosage
Adults
Typical dose is 1.5 mg to 3 mg, 2 to 3 times daily. In severe cases, doses may be increased to 6 mg to 12 mg, 2 to 3 times daily, under strict medical supervision.
Elderly
Initial dose of 1.5 mg once or twice daily, gradually increased if necessary, with caution due to increased sensitivity.
Renal_impairment
Reduced dosage may be required. Use with caution and monitor renal function.
How to Take
Take orally with water, with or without food. Do not chew or crush the tablet.
Mechanism of Action
Bromazepam enhances the effects of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, by binding to benzodiazepine receptors on the GABA-A receptor complex. This increases chloride ion influx into neurons, leading to hyperpolarization and reduced neuronal excitability in the central nervous system.
Pharmacokinetics
Onset
Approximately 30-60 minutes.
Excretion
Primarily excreted in the urine as metabolites.
Half life
Elimination half-life ranges from 10 to 20 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations achieved within 1-2 hours.
Metabolism
Extensively metabolized in the liver, mainly by CYP3A4, to hydroxylated and glucuronidated metabolites, some of which are active.
Side Effects
Contraindications
- Hypersensitivity to bromazepam or other benzodiazepines
- Severe respiratory insufficiency
- Severe hepatic insufficiency
- Sleep apnea syndrome
- Myasthenia gravis
Drug Interactions
Alcohol
Increases CNS depressant effects, leading to enhanced sedation, respiratory depression, and hypotension.
Opioids
Significant risk of profound sedation, respiratory depression, coma, and death.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
May increase bromazepam plasma concentrations, enhancing its effects.
Other CNS depressants (e.g., antidepressants, antihistamines)
Additive CNS depressant effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, confusion, ataxia, diminished reflexes, hypotension, respiratory depression, and in severe cases, coma. Management is supportive, including gastric lavage if recent ingestion, maintenance of airways, and monitoring vital signs. Flumazenil may be used as an antidote, but with caution due to seizure risk.
Pregnancy & Lactation
Not recommended during pregnancy, especially during the first trimester and near term, due to potential risk of congenital malformations and neonatal withdrawal symptoms. Avoid during lactation as it passes into breast milk and may cause sedation in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Extensively studied in numerous clinical trials establishing its efficacy and safety for anxiety and related conditions. Most studies are historical as it is an older drug.
Lab Monitoring
- Liver function tests (LFTs) for long-term therapy
- Renal function monitoring in patients with kidney impairment
Doctor Notes
- Prescribe for the shortest duration possible, typically 2-4 weeks, to minimize the risk of dependence.
- Educate patients on the risks of dependence, withdrawal, and interactions with alcohol/opioids.
- Regularly reassess the need for continued treatment.
Patient Guidelines
- Do not stop taking this medicine abruptly, as it can cause withdrawal symptoms. Tapering off should be done under medical supervision.
- Avoid alcohol and other CNS depressants.
- Report any unusual or severe side effects to your doctor immediately.
- Do not exceed the prescribed dose.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose.
Driving Precautions
This medicine may cause drowsiness, dizziness, or impaired coordination. Avoid driving or operating heavy machinery until you know how it affects you.
Lifestyle Advice
- Practice stress-reduction techniques like meditation or yoga.
- Maintain a regular sleep schedule.
- Avoid excessive caffeine intake.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.