Betanem
Generic Name
Meropenem
Manufacturer
Bicon Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| betanem 500 mg injection | ৳ 700.00 | N/A |
Description
Overview of the medicine
Betanem 500 mg Injection contains Meropenem, a broad-spectrum carbapenem antibiotic used to treat a wide range of severe bacterial infections.
Uses & Indications
Dosage
Adults
Typically 500 mg to 1 g IV every 8 hours, depending on the type and severity of infection. Administered by intravenous infusion over 15-30 minutes or by intravenous bolus over 3-5 minutes.
Elderly
Dosage adjustment based on renal function, similar to adults.
Renal_impairment
Dose reduction required based on creatinine clearance (e.g., lower doses or extended dosing intervals for CrCl <50 mL/min).
How to Take
Administered by intravenous infusion over 15-30 minutes or by intravenous bolus over 3-5 minutes. The powder must be reconstituted with an appropriate diluent before use.
Mechanism of Action
Meropenem inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell death.
Pharmacokinetics
Onset
Rapid onset of action.
Excretion
Primarily renal excretion (approximately 70% as unchanged drug in urine).
Half life
Approximately 1 hour in adults with normal renal function.
Absorption
Rapid and complete absorption after intravenous administration.
Metabolism
Minimally metabolized; primarily hydrolyzed by dehydropeptidase-I (DHP-I) in kidneys, but meropenem is resistant to DHP-I.
Side Effects
Contraindications
- Hypersensitivity to meropenem or other carbapenem antibiotics.
- History of severe hypersensitivity (e.g., anaphylactic reaction, severe skin reaction) to any other type of beta-lactam antibacterial agent (e.g., penicillins, cephalosporins).
Drug Interactions
Probenecid
Concomitant administration with probenecid inhibits the renal excretion of meropenem, resulting in increased plasma concentrations and a prolonged half-life of meropenem.
Valproic acid
Meropenem may decrease valproic acid plasma concentrations, leading to a loss of seizure control.
Oral anticoagulants
Concurrent use may potentiate the anticoagulant effect of warfarin and other oral anticoagulants (monitor INR).
Storage
Store below 25°C. Protect from light. Do not freeze. Reconstituted solutions should be used immediately or within a short period as directed by the manufacturer.
Overdose
In case of overdose, symptomatic and supportive treatment should be given. Meropenem can be removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Meropenem is excreted in breast milk; use with caution during lactation, only if clearly needed.
Side Effects
Contraindications
- Hypersensitivity to meropenem or other carbapenem antibiotics.
- History of severe hypersensitivity (e.g., anaphylactic reaction, severe skin reaction) to any other type of beta-lactam antibacterial agent (e.g., penicillins, cephalosporins).
Drug Interactions
Probenecid
Concomitant administration with probenecid inhibits the renal excretion of meropenem, resulting in increased plasma concentrations and a prolonged half-life of meropenem.
Valproic acid
Meropenem may decrease valproic acid plasma concentrations, leading to a loss of seizure control.
Oral anticoagulants
Concurrent use may potentiate the anticoagulant effect of warfarin and other oral anticoagulants (monitor INR).
Storage
Store below 25°C. Protect from light. Do not freeze. Reconstituted solutions should be used immediately or within a short period as directed by the manufacturer.
Overdose
In case of overdose, symptomatic and supportive treatment should be given. Meropenem can be removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Meropenem is excreted in breast milk; use with caution during lactation, only if clearly needed.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific to manufacturer guidelines.
Availability
Available in hospitals, clinics, and pharmacies (with prescription)
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent (for generic Meropenem)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trial data are available for meropenem, supporting its efficacy and safety in various severe bacterial infections.
Lab Monitoring
- Renal function tests (serum creatinine, BUN) before and during treatment.
- Liver function tests (ALT, AST, alkaline phosphatase) periodically.
- Complete blood count (CBC) during prolonged therapy.
Doctor Notes
- Emphasize appropriate use of meropenem to prevent the development of antimicrobial resistance.
- Crucial to adjust dosage in patients with renal impairment to avoid accumulation and enhance safety.
- Monitor for signs of CNS toxicity, especially in susceptible patients.
Patient Guidelines
- Complete the full prescribed course of treatment, even if symptoms improve.
- Immediately report any adverse reactions, especially severe skin rashes or diarrhea.
- Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered, unless it is almost time for the next scheduled dose. Do not double the dose to catch up.
Driving Precautions
Meropenem may cause dizziness or seizures in some patients, which could impair the ability to drive or operate machinery. Patients should be cautioned.
Lifestyle Advice
- Maintain adequate hydration during treatment.
- Avoid self-medication and use this antibiotic strictly as prescribed.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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