Betanol
Generic Name
Betanol 50 mg Tablet
Manufacturer
PharmaCorp Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| betanol 50 mg tablet | ৳ 0.77 | ৳ 7.70 |
Description
Overview of the medicine
Betanol 50 mg Tablet is a cardioselective beta-blocker used primarily to treat high blood pressure (hypertension), angina pectoris (chest pain), and certain heart rhythm disorders.
Uses & Indications
Dosage
Adults
Initial dose 25-50 mg once daily, adjusted based on response up to 100 mg once daily.
Elderly
Lower initial doses (e.g., 25 mg daily) may be appropriate; adjust cautiously based on renal function and response.
Renal_impairment
Dose adjustment required. For creatinine clearance 15-35 mL/min, maximum 50 mg daily. For <15 mL/min, maximum 25 mg daily or 50 mg every other day.
How to Take
Take orally with water, with or without food, usually once daily at the same time each day.
Mechanism of Action
Betanol selectively blocks beta-1 adrenergic receptors in the heart, leading to a decrease in heart rate, myocardial contractility, and cardiac output. This reduces blood pressure and the heart's oxygen demand.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily excreted unchanged via the kidneys.
Half life
Approximately 6-7 hours, can extend to 15-30 hours in severe renal impairment.
Absorption
Incompletely absorbed from the gastrointestinal tract; approximately 50% oral bioavailability. Peak plasma concentrations reached within 2-4 hours.
Metabolism
Minimally metabolized by the liver; most of the drug is excreted unchanged.
Side Effects
Contraindications
- Sinus bradycardia
- Second or third-degree heart block
- Cardiogenic shock
- Decompensated heart failure
- Severe peripheral arterial disease
- Hypotension
Drug Interactions
NSAIDs
May reduce the antihypertensive effect of Betanol.
Digoxin
Increased risk of bradycardia.
Clonidine
Withdraw Betanol slowly before discontinuing clonidine to avoid rebound hypertension.
Verapamil/Diltiazem
May lead to severe bradycardia and hypotension.
Insulin/Oral hypoglycemic agents
May mask symptoms of hypoglycemia and potentiate hypoglycemic effect.
Storage
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe bradycardia, hypotension, acute cardiac failure, bronchospasm. Management involves gastric lavage, activated charcoal, and supportive treatment such as atropine, glucagon, vasopressors, and intravenous fluids.
Pregnancy & Lactation
Pregnancy Category D. Betanol crosses the placental barrier and appears in breast milk. Use only if potential benefit justifies the potential risk to the fetus or infant.
Side Effects
Contraindications
- Sinus bradycardia
- Second or third-degree heart block
- Cardiogenic shock
- Decompensated heart failure
- Severe peripheral arterial disease
- Hypotension
Drug Interactions
NSAIDs
May reduce the antihypertensive effect of Betanol.
Digoxin
Increased risk of bradycardia.
Clonidine
Withdraw Betanol slowly before discontinuing clonidine to avoid rebound hypertension.
Verapamil/Diltiazem
May lead to severe bradycardia and hypotension.
Insulin/Oral hypoglycemic agents
May mask symptoms of hypoglycemia and potentiate hypoglycemic effect.
Storage
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe bradycardia, hypotension, acute cardiac failure, bronchospasm. Management involves gastric lavage, activated charcoal, and supportive treatment such as atropine, glucagon, vasopressors, and intravenous fluids.
Pregnancy & Lactation
Pregnancy Category D. Betanol crosses the placental barrier and appears in breast milk. Use only if potential benefit justifies the potential risk to the fetus or infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (hypothetical)
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Ongoing post-marketing surveillance and comparative effectiveness research continues to evaluate Betanol's long-term outcomes and safety profile.
Lab Monitoring
- Regular monitoring of blood pressure and heart rate.
- Assessment of renal function (serum creatinine, BUN) periodically.
Doctor Notes
- Emphasize gradual withdrawal of Betanol to avoid rebound effects.
- Careful titration is crucial, especially in elderly patients or those with renal impairment.
- Educate patients on symptoms of bradycardia and hypotension.
Patient Guidelines
- Do not stop taking Betanol suddenly without consulting your doctor.
- Monitor your blood pressure and heart rate regularly as advised by your doctor.
- Report any unusual side effects, especially difficulty breathing or severe dizziness.
- Avoid driving or operating machinery if you experience dizziness or fatigue.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or fatigue, especially at the beginning of treatment or when the dose is changed. Patients should be warned about driving or operating machinery until they know how they react to Betanol.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as approved by your doctor.
- Avoid smoking and limit alcohol consumption.
- Manage stress effectively through relaxation techniques.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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