Betno-CL Cream/Ointment
Generic Name
Betamethasone + Clioquinol
Manufacturer
Various local manufacturers
Country
Bangladesh
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Description
Overview of the medicine
Betno-CL is a combination topical preparation containing Betamethasone (a potent corticosteroid) and Clioquinol (an antibacterial and antifungal agent). It is used to treat various inflammatory skin conditions that are complicated by secondary bacterial or fungal infections.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin area once or twice daily, as directed by a physician. Gently rub in.
Elderly
No specific dose adjustment required, but caution is advised in elderly patients with thin skin or comorbidities.
Renal_impairment
No dose adjustment required for topical use, as systemic absorption is minimal.
How to Take
For external use only. Apply thinly and evenly to the affected area. Do not use on the face for prolonged periods or under occlusive dressings unless specifically advised by a doctor.
Mechanism of Action
Betamethasone acts as an anti-inflammatory, antipruritic, and vasoconstrictive agent, reducing swelling, itching, and redness. Clioquinol exerts antibacterial and antifungal effects, preventing the growth of susceptible microorganisms that may infect the skin.
Pharmacokinetics
Onset
Local symptomatic relief typically within a few days.
Excretion
Primarily excreted renally if systemically absorbed.
Half life
Not extensively studied for topical application; systemic half-life of betamethasone is around 5.6 hours.
Absorption
Minimal systemic absorption through intact skin. Absorption increases with inflammation, skin barrier damage, and occlusive dressings.
Metabolism
Metabolized primarily in the liver if systemically absorbed.
Side Effects
Contraindications
- Hypersensitivity to betamethasone, clioquinol, or any excipients.
- Viral skin infections (e.g., herpes simplex, varicella).
- Tuberculosis of the skin.
- Acne vulgaris and rosacea.
- Perioral dermatitis.
- Primary cutaneous fungal or bacterial infections without concomitant inflammation.
Drug Interactions
0
Systemic absorption is minimal, so significant drug interactions are unlikely with topical use. However, prolonged use over large areas or under occlusion might lead to systemic corticosteroid effects, potentially interacting with oral corticosteroids or drugs affecting CYP3A4.
Storage
Store below 30°C, protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause acute systemic toxicity. However, prolonged or excessive use of corticosteroids can lead to local side effects (skin atrophy) or systemic effects (Cushing's syndrome, adrenal suppression) due to increased absorption. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy or lactation should only be considered if the potential benefit outweighs the potential risk to the fetus or infant. Consult a doctor. Avoid applying on breasts if breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to betamethasone, clioquinol, or any excipients.
- Viral skin infections (e.g., herpes simplex, varicella).
- Tuberculosis of the skin.
- Acne vulgaris and rosacea.
- Perioral dermatitis.
- Primary cutaneous fungal or bacterial infections without concomitant inflammation.
Drug Interactions
0
Systemic absorption is minimal, so significant drug interactions are unlikely with topical use. However, prolonged use over large areas or under occlusion might lead to systemic corticosteroid effects, potentially interacting with oral corticosteroids or drugs affecting CYP3A4.
Storage
Store below 30°C, protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause acute systemic toxicity. However, prolonged or excessive use of corticosteroids can lead to local side effects (skin atrophy) or systemic effects (Cushing's syndrome, adrenal suppression) due to increased absorption. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy or lactation should only be considered if the potential benefit outweighs the potential risk to the fetus or infant. Consult a doctor. Avoid applying on breasts if breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies
Approval Status
Generally approved worldwide
Patent Status
Off-patent
Clinical Trials
Efficacy and safety studies have demonstrated the benefit of this combination for specific skin conditions.
Doctor Notes
- Caution when applying to the face, intertriginous areas, or in children due to increased absorption and risk of side effects.
- Review treatment after 7-14 days; prolonged use should be avoided.
- Educate patients on proper application technique and potential side effects.
Patient Guidelines
- Wash hands before and after applying the cream/ointment.
- Apply a thin layer to the affected area only.
- Do not cover the treated area with bandages or other dressings unless advised by your doctor.
- Avoid contact with eyes, nose, mouth, and other mucous membranes.
- Do not use for more than 7 days in children without medical advice.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Betno-CL topical preparation is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene to prevent further infections.
- Avoid irritants or allergens that may worsen your skin condition.
- Wear loose, breathable clothing to minimize irritation.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.