Bevaris
Generic Name
Bevacizumab
Manufacturer
Generic Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bevaris 400 mg injection | ৳ 71,000.00 | N/A |
Description
Overview of the medicine
Bevacizumab is a monoclonal antibody that inhibits angiogenesis by targeting Vascular Endothelial Growth Factor (VEGF). It is used to treat various types of cancer.
Uses & Indications
Dosage
Adults
Typically 5-15 mg/kg IV every 2-3 weeks, depending on the specific indication and treatment regimen.
Elderly
No specific dose adjustment generally needed, but monitor closely for adverse effects.
Renal_impairment
No specific dose adjustment required for patients with renal impairment.
How to Take
Administered as an intravenous (IV) infusion over 30-90 minutes, depending on the dose and cycle, by a healthcare professional.
Mechanism of Action
It binds to VEGF, preventing it from interacting with receptors on endothelial cells, thereby inhibiting new blood vessel formation and suppressing tumor growth.
Pharmacokinetics
Onset
Rapid distribution after intravenous infusion.
Excretion
Primarily through catabolic pathways, no specific organ for excretion.
Half life
Approximately 11-20 days.
Absorption
Administered intravenously, resulting in 100% bioavailability.
Metabolism
Degraded via proteolytic catabolism, similar to endogenous IgG.
Side Effects
Contraindications
- Hypersensitivity to bevacizumab or any components of the formulation
- Severe or recurrent bleeding
- Recent hemoptysis
- Gastrointestinal perforation or fistula
- Recent major surgery
Drug Interactions
Sunitinib
Increased risk of microangiopathic hemolytic anemia.
Anticoagulants
Increased risk of hemorrhage.
Chemotherapy agents
Potential for altered pharmacokinetics or increased toxicity with certain agents, monitor closely.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light.
Overdose
There is no specific antidote for bevacizumab overdose. Management should consist of symptomatic and supportive treatment.
Pregnancy & Lactation
Pregnancy Category D. Advise women of reproductive potential to use effective contraception. Advise against breastfeeding due to potential harm to the infant.
Side Effects
Contraindications
- Hypersensitivity to bevacizumab or any components of the formulation
- Severe or recurrent bleeding
- Recent hemoptysis
- Gastrointestinal perforation or fistula
- Recent major surgery
Drug Interactions
Sunitinib
Increased risk of microangiopathic hemolytic anemia.
Anticoagulants
Increased risk of hemorrhage.
Chemotherapy agents
Potential for altered pharmacokinetics or increased toxicity with certain agents, monitor closely.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light.
Overdose
There is no specific antidote for bevacizumab overdose. Management should consist of symptomatic and supportive treatment.
Pregnancy & Lactation
Pregnancy Category D. Advise women of reproductive potential to use effective contraception. Advise against breastfeeding due to potential harm to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months, varies by manufacturer. Refer to the product label.
Availability
Hospitals, Specialized Oncology Clinics
Approval Status
FDA approved (for original drug)
Patent Status
Patent expired for generic versions
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support its efficacy and safety in various oncology indications. Ongoing research explores new indications and biosimilar development.
Lab Monitoring
- Blood pressure monitoring
- Urine protein analysis
- Complete Blood Count (CBC)
- Liver function tests
- Renal function tests
Doctor Notes
- Monitor blood pressure and proteinuria regularly throughout treatment.
- Educate patients on potential adverse effects, especially bleeding events and gastrointestinal perforation symptoms.
- Consider holding treatment before planned surgery due to wound healing risk.
Patient Guidelines
- Report any unusual bleeding, severe abdominal pain, sudden severe headache, or vision changes immediately.
- Adhere strictly to the administration schedule and follow-up appointments.
- Do not stop treatment without consulting your doctor.
Missed Dose Advice
If a dose is missed, contact your healthcare provider immediately to reschedule. Do not double the next dose.
Driving Precautions
May cause fatigue, headache, or visual disturbances. Patients should be cautioned about driving or operating machinery if they experience these symptoms.
Lifestyle Advice
- Maintain good hydration.
- Avoid activities that could cause injury or significant bleeding.
- Report any new or worsening symptoms to your healthcare provider.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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