Bevastim
Generic Name
Bevacizumab
Manufacturer
Hypothetical Pharma Co.
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bevastim 100 mg injection | ৳ 13,925.00 | N/A |
Description
Overview of the medicine
Bevacizumab is a recombinant humanized monoclonal antibody that selectively binds to vascular endothelial growth factor (VEGF), preventing its interaction with receptors on endothelial cells. This inhibits angiogenesis (the formation of new blood vessels), thereby slowing tumor growth and metastasis.
Uses & Indications
Dosage
Adults
Dosage varies by indication and body weight, typically 5 mg/kg, 7.5 mg/kg, 10 mg/kg, or 15 mg/kg administered intravenously every 2 or 3 weeks. Always follow specific oncology treatment protocols.
Elderly
No specific dose adjustments for elderly patients are generally required based on age alone, but careful monitoring for adverse effects is recommended.
Renal_impairment
No specific dose adjustment is required for patients with renal impairment.
How to Take
Administer intravenously as an infusion over 30 to 90 minutes. Do not administer as an intravenous push or bolus. The first infusion should be given over 90 minutes. If well tolerated, the second infusion may be given over 60 minutes. Subsequent infusions may be given over 30 minutes if the 60-minute infusion is well tolerated.
Mechanism of Action
Bevacizumab binds to and neutralizes VEGF, a key mediator of angiogenesis. By inhibiting VEGF, the formation of new blood vessels required for tumor growth and survival is suppressed. This leads to decreased tumor vascularization, reduced blood supply to the tumor, and ultimately, inhibition of tumor growth and metastasis.
Pharmacokinetics
Onset
Pharmacodynamic effects (e.g., reduction in microvascular permeability) may be observed shortly after administration, but clinical anti-tumor effects develop over time.
Excretion
Not eliminated via renal or hepatic pathways in the typical sense; catabolized into small peptides and amino acids.
Half life
Approximately 11 to 20 days (mean 20 days).
Absorption
Administered intravenously, resulting in 100% bioavailability.
Metabolism
Catabolized like endogenous IgG, through proteolysis throughout the body.
Side Effects
Contraindications
- •Hypersensitivity to bevacizumab or any excipients of the product, or to Chinese hamster ovary cell products or other recombinant humanized antibodies.
- •Severe or recurrent hemorrhage, especially hemoptysis or gastrointestinal bleeding.
- •Recent major surgery or unhealed wounds.
Drug Interactions
Sunitinib
Increased risk of microangiopathic hemolytic anemia, severe proteinuria, and hypertension.
Anthracyclines
Potential for increased cardiac dysfunction, though data is limited.
Radiation Therapy
Potential for increased risk of fistula formation, especially in patients with pelvic malignancies.
Platinum/Taxane-based Chemotherapy
Increased risk of severe neutropenia.
Storage
Store in a refrigerator (2°C to 8°C). Do not freeze. Protect from light. Do not shake.
Overdose
There is no specific antidote for bevacizumab overdose. In cases of overdose, patients should be monitored for signs and symptoms of adverse reactions and appropriate supportive care should be instituted.
Pregnancy & Lactation
Pregnancy Category C/D. Bevacizumab may cause fetal harm when administered to a pregnant woman. Advise pregnant women and females of reproductive potential of the potential risk to a fetus. Breastfeeding is not recommended during treatment and for at least 6 months after the last dose due to potential for serious adverse reactions in the breastfed infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored unopened according to manufacturer instructions. Once diluted, use within 24 hours.
Availability
Available in hospitals and specialized oncology centers.
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA) for various cancer indications.
Patent Status
Original patent expired; biosimilars available.
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Global Brand Names
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