Bilaxten
Generic Name
Bilexa
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Bilexa is a non-sedating antihistamine used for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria. It effectively alleviates symptoms such as sneezing, runny nose, itchy eyes, and skin rashes.
Uses & Indications
Dosage
Adults
20 mg once daily.
Elderly
No dose adjustment required for elderly patients.
Renal_impairment
No dose adjustment required for mild to moderate renal impairment. Caution is advised in severe renal impairment.
How to Take
Take the tablet orally once daily on an empty stomach, at least one hour before or two hours after food or fruit juice. Swallow the tablet whole with water.
Mechanism of Action
Bilexa is a selective H1-histamine receptor antagonist. It prevents the binding of histamine to H1 receptors, thereby inhibiting the cascade of allergic reactions.
Pharmacokinetics
Onset
Within 30-60 minutes
Excretion
Mainly excreted unchanged, 95% of the dose in urine (28%) and feces (67%).
Half life
Approximately 14.5 hours
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached in 1-2 hours. Bioavailability is approximately 61%.
Metabolism
Not significantly metabolized by the liver, primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Bilexa or any excipients of the formulation.
Drug Interactions
Diltiazem
Increased plasma concentration of Bilexa. Use with caution.
Cyclosporine
Concomitant use may increase plasma concentrations of both drugs. Monitor closely.
Erythromycin
Increased plasma concentration of Bilexa. Use with caution.
Ketoconazole
Increased plasma concentration of Bilexa. Use with caution.
P-glycoprotein inducers (e.g., Rifampicin)
May decrease plasma concentration of Bilexa. Avoid co-administration.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. No specific antidote is known.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Not recommended during breastfeeding as it is unknown if Bilexa is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
DGDA approved
Patent Status
Off-patent in Bangladesh
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Bilexa in allergic rhinoconjunctivitis and urticaria.
Lab Monitoring
- No specific laboratory monitoring tests are generally required for routine use.
Doctor Notes
- Advise patients to take on an empty stomach for optimal absorption.
- Caution for patients with severe renal impairment.
- Review concomitant medications for potential interactions.
Patient Guidelines
- Take Bilexa on an empty stomach to ensure proper absorption.
- Do not exceed the recommended dose.
- Consult your doctor if symptoms persist or worsen.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Bilexa is generally non-sedating at recommended doses. However, individuals should assess their response before driving or operating machinery.
Lifestyle Advice
- Identify and avoid allergens that trigger your symptoms.
- Maintain good hygiene to reduce exposure to allergens.
- Avoid alcohol consumption as it may enhance drowsiness.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.