biomolipon
Generic Name
Alpha-lipoic acid injection
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| biomolipon 600 mg injection | ৳ 820.00 | N/A |
Description
Overview of the medicine
Biomolipon 600 mg Injection contains Alpha-lipoic acid, a powerful antioxidant used primarily to treat symptoms of peripheral neuropathy, especially diabetic neuropathy. It helps improve nerve function and reduce symptoms like numbness, tingling, and pain.
Uses & Indications
Dosage
Adults
600 mg intravenously once daily, administered slowly over at least 30 minutes, for an initial course of 2-4 weeks. This is usually followed by oral maintenance therapy.
Elderly
No specific dose adjustment typically required, but caution is advised in patients with significant renal or hepatic impairment.
Renal_impairment
No specific dose adjustment is generally necessary, but careful monitoring is recommended.
How to Take
Biomolipon 600 mg Injection is administered by slow intravenous infusion over at least 30 minutes, after diluting the concentrate. It should not be given as a rapid bolus injection.
Mechanism of Action
Alpha-lipoic acid functions as a potent antioxidant, neutralizing free radicals and reducing oxidative stress. It also chelates metal ions, regenerates other antioxidants (e.g., vitamins C and E), improves nerve blood flow, and enhances nerve conduction velocity. It plays a role in glucose metabolism and insulin sensitivity.
Pharmacokinetics
Onset
Acute antioxidant effects are immediate after IV administration. Clinical improvement in neuropathic symptoms typically observed after several weeks of continuous treatment.
Excretion
Primarily excreted via the kidneys as metabolites.
Half life
Approximately 20-50 minutes. Despite the short half-life, its therapeutic effects are sustained due to accumulation in tissues and active metabolites.
Absorption
Rapidly absorbed after intravenous administration, leading to 100% bioavailability, bypassing first-pass metabolism.
Metabolism
Extensively metabolized in the liver via beta-oxidation and S-methylation pathways.
Side Effects
Contraindications
- •Hypersensitivity to alpha-lipoic acid or any component of the formulation.
- •Children and adolescents due to insufficient clinical experience.
Drug Interactions
Cisplatin
May reduce the efficacy of cisplatin when co-administered.
Insulin and Oral Antidiabetics
Alpha-lipoic acid may potentiate the blood glucose-lowering effects of insulin and oral antidiabetic agents, potentially requiring dose adjustment and close blood glucose monitoring.
Metal compounds (e.g., iron, magnesium, calcium)
Alpha-lipoic acid is a chelator, so concurrent administration with metal compounds should be avoided or separated by several hours.
Storage
Store below 25°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, headache, and severe cases can lead to seizures, lactic acidosis, hypoglycemia, and coagulopathy. Treatment is symptomatic and supportive, including gastric lavage if recent oral ingestion, and careful monitoring of vital signs and blood glucose.
Pregnancy & Lactation
Limited data are available on the use of alpha-lipoic acid during pregnancy and lactation. It should only be used if the potential benefits outweigh the potential risks and under strict medical supervision. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the manufacturing date, check specific packaging for details.
Availability
Pharmacies, Hospitals
Approval Status
Approved in Bangladesh
Patent Status
Generic
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Global Brand Names
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